Chronic expanding hematoma in the retroperitoneal space: a case report
© Syuto et al.; licensee BioMed Central Ltd. 2013
Received: 2 March 2013
Accepted: 11 November 2013
Published: 18 November 2013
Chronic expanding hematoma is a rare condition that develops after surgery, trauma, or injury. It can also develop at any location in the body in the absence of trauma. Clinical findings and various diagnostic imaging modalities can aid in the differential diagnosis of this condition. In general, hematomas are naturally reabsorbed and rarely cause serious problems. However, hematomas that develop slowly without a history of trauma, surgery, or bleeding disorders could be difficult to differentiate from soft tissue neoplasms. In the present case, we describe a patient, without any history or physical evidence of trauma, who exhibited a large chronic expanding hematoma in the retroperitoneal space that resulted in hydronephrosis because of the pressure exerted on the left ureter.
A 69-year-old man presented to our hospital with a swollen lesion in the left flank. A mass, 19 cm in diameter, was detected in the retroperitoneal space by computed tomography. We suspected the presence of a chronic expanding hematoma, soft tissue tumor, or left renal artery aneurysm. Surgical treatment was performed. However, postoperative histopathological examination indicated that the mass was a nonmalignant chronic expanding hematoma. No recurrence was observed during a 2-year follow-up period.
In patients without a history of trauma who present slowly growing masses, the differential diagnosis should include chronic expanding hematoma in addition to cysts and soft tissue tumors. Moreover, the use of magnetic resonance imaging and computed tomography is essential to differentiate between chronic expanding hematoma and soft tissue tumors.
KeywordsHematoma Retroperitoneal Hydronephrosis
Hematomas can develop in many locations of the body as a result of trauma, surgery, or bleeding disorders. The diagnosis of this condition is based on medical history, physical findings, and the results of examinations involving various imaging modalities. Some hematomas persist as slowly expanding, space-occupying masses for months or years, and are termed as chronic expanding hematomas (CEH) . In general, hematomas are naturally reabsorbed and rarely cause serious problems. However, those that develop slowly and progressively in patients with no history of trauma, surgery, or associated bleeding disorders can be difficult to differentiate from soft tissue neoplasms . In the present report, we describe a case of CEH developing in the retroperitoneal space that was associated with hydronephrosis.
A 69-year-old man with no prior history of medication or anticoagulant therapy first noticed a painless swelling in his left flank in 2005. This swelling gradually increased over 6 years, resulting in the formation of a mass in the left flank region. In June 2011, the patient presented to a local hospital after mild pain developed. The patient did not have any definite history of trauma or surgery that could have caused the left abdominal/back lesion. Computed tomography (CT) indicated the presence of a left retroperitoneal mass with left hydronephrosis because of external compression by the mass and a right atrophic kidney. A double J-stent was placed in the left ureter. The serum creatinine level changed from 0.72 mg/dL before double J-stent insertion to 0.53 mg/dL after the treatment.
CEH is a type of hematoma that is most commonly caused by trauma, and has certain other etiologies such as hemorrhagic disorder. Hematomas are often reabsorbed, and gradually decrease in size. However, in rare cases, they may develop slowly and expand progressively over a period of time. In certain cases, CEH may persist and increase in size for more than 1 month after the initial hemorrhagic event . Hematomas in the skeletal muscles or surrounding tissue may develop as a result of a direct shearing force that splits the subcutaneous fat from the underlying fascia, thus potentially creating a large space, which may then fill with blood. Labadie et al.  reported that blood and erythrocyte degradation products, hemoglobin, leukocytes, platelets, and fibrin exert an irritant effect on the surrounding tissue. These factors are believed to induce a mild inflammatory response, which increases vascular wall permeability and bleeding from dilated capillaries in the granulation tissue beneath the capsular wall, thus resulting in the subsequent growth of the hematoma. However, no trigger such as trauma or anticoagulant therapy was identified in the present case.
Reported cases of retropritoneal chronic expanding hematomas
Patient age (years)
Site of the hematoma
Hematoma size (cm)
Kaneko et al 
Above the right kidney
Hamada et al 
At the right iliac fossa
Irisawa et al 
Below the right kidney
Yamazaki et al 
Above the left kidney
Yamada et al 
Above the left kidney
Reid et al 
At the right iliac fossa
Reid et al 
Syuto et sl
Below the left kidney
CEH may be difficult to differentiate from soft tissue tumors (such as hemangiopericytomas and cavernous hemangiomas), sarcomas, actinomycosis, and inflammatory pseudotumors . Weiss et al.  reported that hematomas are associated with approximately 5% of malignant fibrous histiocytomas.
Various imaging modalities have been used for the diagnosis of CEH. It has been stated that a dynamic CT scanning can detect a rim enhancement in the arterial phase in such cases, because granulation tissue with vascular channels is distributed within the hematoma capsule [2, 9]. In the present case, enhanced CT revealed a partly enhanced rim. Although MRI is inferior to CT in identifying calcification or spatial resolution, MRI is more sensitive than CT in the diagnosis of hematomas. The signal within the lesion on MRI can vary with the passage of time, indicating time-related changes in hemoglobin levels. High signal intensity on T1-weighted images are attributable to the presence of methemoglobin within the hematoma. A few soft tissue tumors such as lipomas, liposarcomas, and hemangiomas also yield enhanced high signal intensity on T1-weighted images. However, it can be difficult to differentiate hematomas from malignant soft tissue tumors based on clinical and radiological findings because of the time-related changes in MRI signals . Liu et al. reported that CEH should be considered in the differential diagnosis for soft tissue masses that exhibit internal hemorrhage and fibrous pseudocapsule during unenhanced T1- and T2-weighted MRI. If the contrast enhancement is patchy within the lesion, a diagnosis of hemorrhagic sarcomas should be considered . In the present case, high signal intensity was predominantly observed on both T1-and T2-weighted images, except for an area of low signal intensity that represented a wall of collagenous fibrous tissue on the peripheral rim. A T2-weighted image of MRI in the present case showed a “mosaic sign,” which meant that the lesion involved repeated bleeding because it contained a mosaic of various signal intensities representing fresh and old blood . These atypical MRI findings indicated the presence of CEH.
The optimal treatment option for CEH is complete excision of the hematoma together with its fibrous capsule. Aspiration of the liquid or drainage could result in serious bleeding or recurrence [9, 13]. However, hematomas are often difficult to remove because of adhesion to the surrounding tissue and abundant neovascularization beneath the capsule. By using CT in particular, the presence of new capillaries and granulation tissue can be easily identified if contrast material is used .
In the present case, the left kidney was hydronephrotic. Therefore, a double J-stent was placed in the left ureter to aid in identifying and preventing injury to the left ureter. The double J-stent was removed 2 months postoperatively, and the hydronephrosis in the left kidney had resolved. To our knowledge, a hematoma of a comparable size as the one reported in the present case, accompanied with left hydronephrosis, has never been reported in the literature. Moreover, in the present case, the etiology of CEH was unclear and could not be determined during surgery. Although no recurrence was evident at the 2-year follow-up, it is essential to further follow-up the patient carefully.
We reported the case of a patient with a huge CEH located in the retroperitoneal space that resulted in hydronephrosis. MRI may be useful for differentiating between CEH and malignant soft tissue tumors. Complete removal of the CEH resulted in resolution of hydronephrosis and no recurrence of CEH at the 2-year follow-up.
Written informed consent was obtained from the patient for publication of this Case report and any accompanying images.
Chronic expanding hematomas
Magnetic resonance imaging.
We thank the patient for allowing us to report his medical report as a case report.
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