Coexistence between renal cell cancer and Hodgkin's lymphoma: A rare coincidence
© Jimenez I; licensee BioMed Central Ltd. 2006
Received: 11 November 2005
Accepted: 20 March 2006
Published: 20 March 2006
Renal cell carcinoma is the most common kidney tumor in adults and accounts for approximately 3% of adult malignancies. An increased incidence of second malignancies has been well documented in a number of different disorders, such as head and neck tumors, and hairy cell leukemia. In addition, treatment associated second malignancies (usually leukemias and lymphomas but also solid tumors) have been described in long term survivors of Hodgkin's lymphoma (HL), Non Hodgkin's lymphoma and in various pediatric tumors.
We present the case of a 66 year-old woman with abdominal pain and dyspnea. We performed a thorax CT scan that showed lymph nodes enlargement and subsequently by presence of abdominal pain was performed an abdominal and pelvis CT scan that showed a right kidney tumor of 4 × 5 cms besides of abdominal lymph nodes enlargement. A radical right nephrectomy was designed and Hodgkin's lymphoma was diagnosed in the abdominal lymph nodes while renal cell tumor exhibited a renal cell cancer. Patient received EVA protocol achieving complete response.
We described the first case reported in the medical literature of the coexistence between Hodgkin's lymphoma and renal cell cancer. Previous reports have shown the relationship of lymphoid neoplasms with solid tumors, but they have usually described secondary forms of cancer related to chemotherapy.
We present the case of a 66 year-old woman with history of intense smoking (pack years of 50), diabetes mellitus detected a prior year and COPD (Chronic obstructive pulmonary disease) diagnosed 8 prior months. She came at the emergency department to receive medical attention by presenting fever, loss of weight and dyspnea. During the initial evaluation was performed a thorax CT scan that showed lymph nodes enlargement and subsequently by presence of abdominal pain was performed an abdominal and pelvis CT scan that showed a right kidney tumor of 4 × 5 cms besides of abdominal lymph nodes enlargement. A radical right nephrectomy was designed, prior to surgery we performed an spirometer study that revealed a moderate obstruction pattern. The surgical procedure included lymph nodes remotion. Histopathology study revealed Hodgkin's lymphoma involving right kidney, abdominal lymph nodes, ureter and liver. Immunostaining showed positiveness for CD15, CD30 and LMP-1 while CD3, EMA and ALK were negative. Histological study also reported a clear renal cell cancer, degree II, involving only the right kidney without extension to any other structure. Surgical resection was complete and margins were negative for cancer, diffuse glomerulosclerosis also was found. After surgical procedure we did a bilateral bone marrow biopsy that was negative for lymphoma. Staging studies showed an IV b stage and 4 unfavorable factors (stage IV, hemoglobin 7,2 g/dl, albumin 3.2 g/dl and lymphocytes <0.6) at diagnosis. We performed an echocardiography study that revealed light enlargement of right cavities, diastolic dysfunction and moderate pulmonary hypertension. The patient received chemotherapy with a protocol called EVA (etoposide, vinblastine and doxorubicin). After third cycle we documented complete response, fact that was obtained after completed the chemotherapy scheme. At present she continues asymptomatic without evidence of disease activity. We present a figure 1 that shows in the panel A and B a tumor involving the right kidney, measuring 4 × 5 cms while panel C shows the CD 30 immunostain being positive in the neoplasms cells and panel D shows a transitional area between renal cell cancer and Hodgkin's lymphoma.
We described the first case reported in the medical literature of the coexistence between Hodgkin's lymphoma and renal cell cancer. Previous reports have shown the relationship of lymphoid neoplasms with solid tumors, but they have usually described secondary forms of cancer related to chemotherapy. Nishikubo et al, reported a case of a 63 year-old man that developed renal cell cancer 8 years after treatment for Hodgkin's lymphoma.  Due to the presence of pulmonary hypertension and lung injury related to COPD we decided to use the EVA protocol to treat this patient. Canellos et al, described the employment of the EVA protocol to treat HL patients as a first line therapy including advances stages, 51 patients, even 12 with bulky disease received this protocol, 10 of which received concomitant radiotherapy.  EVA protocol achieved complete response in 94% and free progression survival of 57% at 111 months since diagnosis. Our patient is free disease at 2 months since the last course of chemotherapy. She presented 4 unfavorable factors, fact that predicts a possible recurrence. Multiple cancers developing after chemotherapy and radiotherapy have been described but we presented a peculiar case of simultaneous presentation of a solid tumor an HL. [23, 24] It is worthwhile to look for second malignancies and get additional biopsies in case of unclear finding. This coincidence appears to be rare. We diagnosed annually 10 cases of renal cell carcinoma and 20 cases a year of Hodgkin's lymphoma.
Written consent was obtained from the patient and their relative for publication of the study.
- De Vita VT, Hellman S, Rosenberg SA: Cancer principles and practice of oncology. 1993, Philadelphia: JB Lippincott Co, 4Google Scholar
- Haskell CM, Berek JS, editors: Cancer treatment. 1995, Philadelphia: WB Saunders Co, 4
- Maher ER, Bentley E, Yates JR: Mapping of Von Hippel-Lindau disease to chromosome 3p confirmed by genetic linkage analysis. J neurol Sci. 1990, 100: 27-30. 10.1016/0022-510X(90)90008-B.View ArticlePubMedGoogle Scholar
- Licciardello JT, Spitz MR, Hong WK: Multiple primary cancer in patients with cancer of the head and neck: second cancer of the head and neck, esophagus and lung. Int J Radiat Oncol Biol Phys. 1989, 17: 467-76.View ArticlePubMedGoogle Scholar
- Cooper JS, Paiak TF, Rubin P: Second malignancies in patients who have head and neck cancer. Int J Radiat Oncol Biol Phys. 1989, 17: 449-56.View ArticlePubMedGoogle Scholar
- Jacobs RH, Vokes EE, Gollumb HM: Second malignancies in hairy cell leukemia. Cancer. 1985, 56: 1462-7.View ArticlePubMedGoogle Scholar
- Rodriguez MA, Fuller LM, Zimmerman SO: Hodgkin's disease: study of treatment intensities and incidences of second malignancies. Ann Oncol. 1993, 4: 125-31.PubMedGoogle Scholar
- Valagussa P: Second neoplasms following treatment of Hodgkin's disease. Curr Opinion Oncol. 1993, 5: 805-11.View ArticleGoogle Scholar
- Travis LB, Curtis RE, Boice JR: Second cancers following NHL. Cancer. 1991, 67: 2002-9.View ArticlePubMedGoogle Scholar
- Travis LB, Curtis RE, Glimelius B: Second cancers among long term survivors of NHL. J Natl Cancer Inst. 1993, 85 (23): 1932-7.View ArticlePubMedGoogle Scholar
- Lavey RS, Eby NL, Prosnitz LR: Impact on second malignancies risk of the combined use of radiation and chemotherapy for lymphomas. Cancer. 1990, 66: 80-6.View ArticlePubMedGoogle Scholar
- Smith MB, Xue X, Strong L: Forty-year experience with second malignancies after treatment of childhood cancers: analysis of outcome following the development of the secondary malignancy. J Pediatr Surg. 1993, 28: 1342-9.View ArticlePubMedGoogle Scholar
- Hartley AL, Birch JM, Blair V: Second primary neoplasms in a population based series of patients diagnosed with renal tumours in childhood. Med Pediatr Oncol. 1994, 22: 318-24.View ArticlePubMedGoogle Scholar
- Nielsen B, Braide I, Hasselbach H: Evidence for an association between hairy cell leukemia and renal cell and colorectal carcinoma. Cancer. 1992, 70: 2087-90.View ArticlePubMedGoogle Scholar
- Foa P, Iurlo A, Maiolo AT: Renal cancer after busulphan treatment for chronic myeloid leukemia: therapeutic implications. Ann Oncol. 1993, 4 (6): 521-2.PubMedGoogle Scholar
- Cooper GL, Shaffer DW, Raval HB: Fine needle aspiration biopsy of multiple myeloma in a patient with renal cell carcinoma: a case report. Diagn Cytopathol. 1993, 9: 551-4.View ArticlePubMedGoogle Scholar
- Sakai A, Kawano M, Kuramoto A: Interleukin 6 produced by renal cell carcinoma cells and progression of multiple myeloma. N Engl J Med. 1991, 1893-4.Google Scholar
- Rodriguez Díaz-Pavón J, Pugh W, Cabanillas F: Simultaneous presentation of hairy cell leukemia and follicular small cleaved lymphoma in a patient with previous diagnosis of renal cell carcinoma. Hematol Oncol. 1995, 3: 63-7.View ArticleGoogle Scholar
- Lokich JJ: Secondary uncommon solid neoplasms in cured Hodgkin's disease and follow-up of the original B-DOPA chemotherapy patient group. Am J Clin Oncol. 1990, 13 (3): 247-50.View ArticlePubMedGoogle Scholar
- Davis BE, Sogani PC, Herr HW: Association of primary germ cell tumor of the testis and renal cell carcinoma. J Urol. 1993, 150: 1489-91.PubMedGoogle Scholar
- Nishikubo CY, Kunkei LA, Figlin R: An association between renal cell carcinoma and lymphoid malignancies. Cancer. 1996, 78: 2421-6. 10.1002/(SICI)1097-0142(19961201)78:11<2421::AID-CNCR21>3.0.CO;2-1.View ArticlePubMedGoogle Scholar
- Canellos GP, Gollub J, Neyberg D: Primary systemic treatment of advanced Hodgkin's disease with EVA. Annals of Oncology. 2003, 14: 268-72. 10.1093/annonc/mdg076.View ArticlePubMedGoogle Scholar
- Tabacu E, Galie N, Mitrea M: Multiple primary cancers with different localizations and hystologic types. Pneumologia. 2003, 52 (1): 51-3.PubMedGoogle Scholar
- Marquez-Moreno AL, Manans-Uxo J, Amores-Ramirez F: Synchronous chromophobe renal carcinoma and centrocytic lymphoma. Arch Esp Urol. 2003, 56 (4): 415-7.PubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2490/6/10/prepub
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