Urological oncology

Section edited by Philippe Spiess, Jose Karam and Chris Protzel

This section considers clinical studies relevant to oncological disorders in urology

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  1. Research article

    BAP1 and PBRM1 in metastatic clear cell renal cell carcinoma: tumor heterogeneity and concordance with paired primary tumor

    BAP1 and PBRM1 are frequently mutated in primary clear cell renal cell carcinoma (ccRCC) tumors; however, the frequency and clinical relevance of these mutations in metastatic ccRCC tumors is unknown. Addition...

    Jeanette E. Eckel-Passow, Daniel J. Serie, John C. Cheville, Thai H. Ho, Payal Kapur, James Brugarolas, R. Houston Thompson, Bradley C. Leibovich, Eugene D. Kwon, Richard W. Joseph and Alexander S. Parker

    BMC Urology 2017 17:19

    Published on: 21 March 2017

  2. Review

    miRNAs associated with prostate cancer risk and progression

    Prostate cancer is the most common malignancy among men in the US. Though considerable improvement in the diagnosis of prostate cancer has been achieved in the past decade, predicting disease outcome remains a...

    Hung N. Luu, Hui-Yi Lin, Karina Dalsgaard Sørensen, Olorunseun O. Ogunwobi, Nagi Kumar, Ganna Chornokur, Catherine Phelan, Dominique Jones, LaCreis Kidd, Jyotsna Batra, Kosj Yamoah, Anders Berglund, Robert J. Rounbehler, Mihi Yang, Sang Haak Lee, Nahyeon Kang…

    BMC Urology 2017 17:18

    Published on: 20 March 2017

  3. Research article

    Aortic calcification burden predicts deterioration of renal function after radical nephrectomy

    Radical nephrectomy for renal cell carcinoma (RCC) is a risk factor for the development of chronic kidney disease (CKD), and the possibility of postoperative deterioration of renal function must be considered ...

    Ken Fukushi, Shingo Hatakeyama, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Osamu Soma, Teppei Matsumoto, Itsuto Hamano, Takuma Narita, Atsushi Imai, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Yuriko Terayama, Tomihisa Funyu and Chikara Ohyama

    BMC Urology 2017 17:13

    Published on: 6 February 2017

  4. Research article

    Genetic polymorphisms in key hypoxia-regulated downstream molecules and phenotypic correlation in prostate cancer

    In this study we sought if, in their quest to handle hypoxia, prostate tumors express target hypoxia-associated molecules and their correlation with putative functional genetic polymorphisms.

    Avelino Fraga, Ricardo Ribeiro, André Coelho, José Ramon Vizcaíno, Helena Coutinho, José Manuel Lopes, Paulo Príncipe, Carlos Lobato, Carlos Lopes and Rui Medeiros

    BMC Urology 2017 17:12

    Published on: 31 January 2017

  5. Research article

    Do men regret prostate biopsy: Results from the PiCTure study

    Understanding men’s experience of prostate biopsy is important as the procedure is common, invasive and carries potential risks. The psychological aspects of prostate biopsy have been somewhat neglected. The a...

    Catherine Coyle, Eileen Morgan, Frances J. Drummond, Linda Sharp and Anna Gavin

    BMC Urology 2017 17:11

    Published on: 26 January 2017

  6. Research article

    Preoperative lipiodol marking and its role on survival and complication rates of CT-guided cryoablation for small renal masses

    Partial nephrectomy for small renal masses (SRM) may be useful for preserving renal function, but is technically more difficult than radical nephrectomy. Cryoablation may be performed under local anesthesia. T...

    Fumiya Hongo, Yasuhiro Yamada, Takashi Ueda, Terukazu Nakmura, Yoshio Naya, Kazumi Kamoi, Koji Okihara, Yusuke Ichijo, Tsuneharu Miki, Kei Yamada and Osamu Ukimura

    BMC Urology 2017 17:10

    Published on: 18 January 2017

  7. Research article

    Neutrophil-lymphocyte ratio as a predictive biomarker for response to high dose interleukin-2 in patients with renal cell carcinoma

    Immunotherapy with high-dose interleukin-2 (HD-IL2) results in long-term survival in some metastatic renal cell carcinoma (mRCC) patients but has significant acute toxicities. Biomarkers predicting response to...

    James A. Kuzman, David D. Stenehjem, Joseph Merriman, Archana M. Agarwal, Shiven B. Patel, Andrew W. Hahn, Anitha Alex, Dan Albertson, David M. Gill and Neeraj Agarwal

    BMC Urology 2017 17:1

    Published on: 5 January 2017

  8. Research article

    Patient preferences for treatment of castration-resistant prostate cancer in Japan: a discrete-choice experiment

    Up to a fifth of patients diagnosed with prostate cancer (PC) will develop castration-resistant prostate cancer (CRPC), which has been associated with a poor prognosis. The aim of this study was to consider th...

    Hiroji Uemura, Nobuaki Matsubara, Go Kimura, Akito Yamaguchi, Dianne Athene Ledesma, Marco DiBonaventura, Ateesha F. Mohamed, Enrique Basurto, Ian McKinnon, Ed Wang, Kristen Concialdi, Aya Narimatsu and Yasuko Aitoku

    BMC Urology 2016 16:63

    Published on: 4 November 2016

  9. Research article

    Cancer-specific and overall survival in patients with recurrent prostate cancer who underwent salvage extended pelvic lymph node dissection

    The aim was to evaluate cancer-specific survival (CSS) and overall survival (OS) in patients with prostate cancer (PCa) recurrence who underwent salvage extended pelvic lymph node dissection (ePLND), taking in...

    Daniar K. Osmonov, Alexey V. Aksenov, David Trick, Carsten M. Naumann, Moritz F. Hamann, Amr Abou Faddan and Klaus-Peter Jünemann

    BMC Urology 2016 16:56

    Published on: 6 September 2016

  10. Research article

    Clinical significance of CDH13 promoter methylation as a biomarker for bladder cancer: a meta-analysis

    Methylation of the tumor suppressor gene H-cadherin (CDH13) has been reported in many cancers. However, the clinical effect of the CDH13 methylation status of patients with bladder cancer remains to be clarified.

    Feng Chen, Tao Huang, Yu Ren, Junjun Wei, Zhongguan Lou, Xue Wang, Xiaoxiao Fan, Yirun Chen, Guobin Weng and Xuping Yao

    BMC Urology 2016 16:52

    Published on: 30 August 2016

  11. Research article

    A Korean multi-center, real-world, retrospective study of first-line pazopanib in unselected patients with metastatic renal clear-cell carcinoma

    The efficacy and/or tolerability of pazopanib in patients with metastatic renal cell carcinoma (mRCC) have been found to differ in Western and Asian populations. This retrospective multicenter study analyzed t...

    Moon Jin Kim, Se Hoon Park, Jae-Lyun Lee, Se-Hoon Lee, Su Jin Lee and Ho Yeong Lim

    BMC Urology 2016 16:46

    Published on: 2 August 2016

  12. Research article

    Quality of life effects of androgen deprivation therapy in a prostate cancer cohort in New Zealand: can we minimize effects using a stratification based on the aldo-keto reductase family 1, member C3 rs12529 gene polymorphism?

    Androgen deprivation therapy (ADT) is an effective palliation treatment in men with advanced prostate cancer (PC). However, ADT has well documented side effects that could alter the patient’s health-related qu...

    Nishi Karunasinghe, Yifei Zhu, Dug Yeo Han, Katja Lange, Shuotun Zhu, Alice Wang, Stephanie Ellett, Jonathan Masters, Megan Goudie, Justin Keogh, Benji Benjamin, Michael Holmes and Lynnette R. Ferguson

    BMC Urology 2016 16:48

    Published on: 2 August 2016

  13. Research article

    10-Year experience regarding the reliability and morbidity of radio guided lymph node biopsy in penile cancer patients and the associated radiation exposure of medical staff in this procedure

    The guidelines of the European Association of Urologists (EAU), of the German Society of Nuclear Medicine (DGN), and the European Society for Medical Oncology (ESMO) recommend sentinel lymph node biopsy (SLNB)...

    Ulf Lützen, Carsten Maik Naumann, Jens Dischinger, Marlies Marx, René Baumann, Yi Zhao, Michael Jüptner, Daniar Osmonov, Katrin Bothe, Klaus-Peter Jünemann and Maaz Zuhayra

    BMC Urology 2016 16:47

    Published on: 2 August 2016

  14. Research article

    Multi-disciplinary surgical approach to the management of patients with renal cell carcinoma with venous tumor thrombus: 15 year experience and lessons learned

    The management of patients with renal cell carcinoma (RCC) with venous tumor thrombus (VTT) is challenging. We report our 15 year experience in the management of patients with RCC with VTT utilizing a multidis...

    Bishoy A. Gayed, Ramy Youssef, Oussama Darwish, Payal Kapur, Aditya Bagrodia, James Brugarolas, Ganesh Raj, J. Michael DiMaio, Arthur Sagalowsky and Vitaly Margulis

    BMC Urology 2016 16:43

    Published on: 19 July 2016

  15. Research article

    Obesity is associated with increased risk of invasive penile cancer

    To validate the association between obesity and penile cancer at a population level, we conducted a matched case–control study linking the Iowa Department of Motor Vehicles Drivers’ License Database (DLD) with...

    Kerri T. Barnes, Bradley D. McDowell, Anna Button, Brian J. Smith, Charles F. Lynch and Amit Gupta

    BMC Urology 2016 16:42

    Published on: 13 July 2016

  16. Research article

    Clinical characteristics of XP11.2 translocation/TFE3 gene fusion renal cell carcinoma: a systematic review and meta-analysis of observational studies

    Renal cell carcinoma (RCC) associated with Xp11.2 translocation/TFE3 gene fusion (Xp11.2 RCC) is a rare subtype of RCC which is firstly described as a distinct entity in 2004 so that clinical characteristics o...

    Xiangming Cheng, Weidong Gan, Gutian Zhang, Xiaogong Li and Hongqian Guo

    BMC Urology 2016 16:40

    Published on: 11 July 2016

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