Voiding dysfunction

Section edited by Cosimo de Nunzio and Stephen Kraus

This section considers submissions relating to the management of urological male and female voiding dysfunction, including neurological disorders and prostatic diseases. (NOTE: Articles dealing with the diagnosis or treatment of prostate cancer should be submitted to the "Urological oncology" section)

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  1. Research article

    A retrospective study of treatment persistence and adherence to α-blocker plus antimuscarinic combination therapies, in men with LUTS/BPH in the Netherlands

    To assess treatment persistence and adherence in men ≥45 years of age with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH), using prescription records from the Netherland...

    Marcus J. Drake, Sally Bowditch, Emilio Arbe, Zalmai Hakimi, Florent Guelfucci, Ikbel Amri and Jameel Nazir

    BMC Urology 2017 17:36

    Published on: 22 May 2017

  2. Research article

    The role of flower pollen extract in managing patients affected by chronic prostatitis/chronic pelvic pain syndrome: a comprehensive analysis of all published clinical trials

    Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is still a challenge to manage for all physicians. We feel that a summary of the current literature and a systematic review to evaluate the therapeuti...

    Tommaso Cai, Paolo Verze, Roberto La Rocca, Umberto Anceschi, Cosimo De Nunzio and Vincenzo Mirone

    BMC Urology 2017 17:32

    Published on: 21 April 2017

  3. Research article

    Real life persistence rate with antimuscarinic treatment in patients with idiopathic or neurogenic overactive bladder: a prospective cohort study with solifenacin

    Several studies have shown that the antimuscarinic treatment of overactive bladder is characterized by low long-term persistence rates. We have investigated the persistence of solifenacin in real life by means...

    Marloes J. Tijnagel, Jeroen R. Scheepe and Bertil F. M. Blok

    BMC Urology 2017 17:30

    Published on: 13 April 2017

  4. Research article

    Benign prostatic enlargement can be influenced by metabolic profile: results of a multicenter prospective study

    In last years Metabolic Syndrome (MetS) has been closely associated to Benign Prostatic Enlargement (BPE) Aim of our study is to evaluate the effect of MetS and each single MetS parameter on prostate growth in...

    Mauro Gacci, Arcangelo Sebastianelli, Matteo Salvi, Cosimo De Nunzio, Linda Vignozzi, Giovanni Corona, Tommaso Jaeger, Tommaso Chini, Giorgio Ivan Russo, Mario Maggi, Giuseppe Morgia, Andrea Tubaro, Marco Carini and Sergio Serni

    BMC Urology 2017 17:22

    Published on: 4 April 2017

  5. Research article

    Fulranumab in patients with interstitial cystitis/bladder pain syndrome: observations from a randomized, double-blind, placebo-controlled study

    This study was designed to evaluate the efficacy and safety of fulranumab, a fully human monoclonal antibody directed against nerve growth factor (NGF), for pain relief in patients with interstitial cystitis/b...

    Hao Wang, Lucille J. Russell, Kathleen M. Kelly, Steven Wang and John Thipphawong

    BMC Urology 2017 17:2

    Published on: 5 January 2017

  6. Study protocol

    Protocol for a prospective, randomized study on neurophysiological assessment of lower urinary tract function in a healthy cohort

    Lower urinary tract symptoms are highly prevalent and a large proportion of these symptoms are known to be associated with a dysfunction of the afferent pathways. Diagnostic tools for an objective and reproduc...

    Stéphanie van der Lely, Martina Stefanovic, Melanie R. Schmidhalter, Marta Pittavino, Reinhard Furrer, Martina D. Liechti, Martin Schubert, Thomas M. Kessler and Ulrich Mehnert

    BMC Urology 2016 16:69

    Published on: 25 November 2016

  7. Research article

    New medical treatments for lower urinary tract symptoms due to benign prostatic hyperplasia and future perspectives

    Lower Urinary Tract Symptoms (LUTS) in men are a common clinical problem in urology and have been historically strictly linked to benign prostatic hyperplasia (BPH), which may lead to bladder outlet obstructio...

    Simone Albisinni, Ibrahim Biaou, Quentin Marcelis, Fouad Aoun, Cosimo De Nunzio and Thierry Roumeguère

    BMC Urology 2016 16:58

    Published on: 15 September 2016

  8. Research article

    Preserved micturition after intradetrusor onabotulinumtoxinA injection for treatment of neurogenic bladder dysfunction in Parkinson’s disease

    To assess the efficacy and safety of intradetrusor onabotulinumtoxinA (OnabotA) injection treatment in patients with neurogenic lower urinary tract dysfunction (NLUTD), especially for patients with Parkinson d...

    Stephanie C. Knüpfer, Susanne A. Schneider, Mareike M. Averhoff, Carsten M. Naumann, Günther Deuschl, Klaus-Peter Jünemann and Moritz F. Hamann

    BMC Urology 2016 16:55

    Published on: 5 September 2016

  9. Research article

    The combination of herbal medicine Weng-li-tong with Tolterodine may be better than Tolterodine alone in the treatment of overactive bladder in women: a randomized placebo-controlled prospective trial

    To assess the efficacy and safety of the herbal medicine, Weng-li-tong (WLT) as monotherapy or combined with tolterodine in women with overactive bladder (OAB).

    Dong-dong Xiao, Jian-wei Lv, Xin Xie, Xing-wei Jin, Mu-jun Lu and Yuan Shao

    BMC Urology 2016 16:49

    Published on: 8 August 2016

  10. Research article

    The efficacy of mirabegron additional therapy for lower urinary tract symptoms after treatment with α1-adrenergic receptor blocker monotherapy: prospective analysis of elderly men

    Mirabegron is a β3-adrenoreceptor agonist developed for treatment of overactive bladder (OAB). α1-Adrenergic receptor blockers are effective for lower urinary tract symptoms (LUTS) in male patients. However, t...

    Tomohiro Matsuo, Yasuyoshi Miyata, Katsura Kakoki, Miki Yuzuriha, Akihiro Asai, Kojiro Ohba and Hideki Sakai

    BMC Urology 2016 16:45

    Published on: 29 July 2016

  11. Research article

    An observational study of the use of beclomethasone dipropionate suppositories in the treatment of lower urinary tract inflammation in men

    Nonbacterial prostatitis, together with chronic pelvic pain syndrome, accounts for 90–95 % of prostatitis cases. Anti-inflammatory medications are commonly used to reduce storage/inflammatory symptoms that can...

    Giorgio Bozzini, Marco Provenzano, Nicolò Buffi, Mauro Seveso, Giovanni Lughezzani, Giorgio Guazzoni, Alberto Mandressi and Gianluigi Taverna

    BMC Urology 2016 16:25

    Published on: 8 June 2016

  12. Study protocol

    Probiotics [LGG-BB12 or RC14-GR1] versus placebo as prophylaxis for urinary tract infection in persons with spinal cord injury [ProSCIUTTU]: a study protocol for a randomised controlled trial

    Urinary tract infections [UTIs] are very common in people with Spinal Cord Injury [SCI]. UTIs are increasingly difficult and expensive to treat as the organisms that cause them become more antibiotic resistant...

    Bonsan Bonne Lee, Swee-Ling Toh, Suzanne Ryan, Judy M. Simpson, Kate Clezy, Laetitia Bossa, Scott A. Rice, Obaydullah Marial, Gerard Weber, Jasbeer Kaur, Claire Boswell-Ruys, Stephen Goodall, James Middleton, Mark Tudehope and George Kotsiou

    BMC Urology 2016 16:18

    Published on: 16 April 2016

  13. Research article

    Determinants of peri-operative blood transfusion in a contemporary series of open prostatectomy for benign prostate hyperplasia

    The objective of this study was to determine the factors responsible for peri-operative blood transfusion in a contemporary series of open prostatectomy for benign prostate hyperplasia and thus offer a guide f...

    Mathew Y. Kyei, George O. Klufio, James E. Mensah, Samuel Gepi-Attee, Kwabena Ampadu, Bernard Toboh and Edward D. Yeboah

    BMC Urology 2016 16:17

    Published on: 28 March 2016

  14. Research article

    Uni-axial stretch induces actin stress fiber reorganization and activates c-Jun NH2 terminal kinase via RhoA and Rho kinase in human bladder smooth muscle cells

    Excessive mechanical overload may be involved in bladder wall remodelling. Since the activity of Rho kinase is known to be upregulated in the obstructed bladder, we investigate the roles of the RhoA/Rho kinase...

    Nobuhiro Kushida, Osamu Yamaguchi, Yohei Kawashima, Hidenori Akaihata, Junya Hata, Kei Ishibashi, Ken Aikawa and Yoshiyuki Kojima

    BMC Urology 2016 16:9

    Published on: 29 February 2016

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