From: Clinical significance of subepithelial growth patterns in non-muscle invasive bladder cancer
Variables | Cases (n) | Tumor recurrence | ||||
---|---|---|---|---|---|---|
 |  |  | Univariate | Multivariate | ||
 |  |  | Hazard ratio (95% CI) | p value | Hazard ratio (95% CI) | p value |
T stage | Â | Â | Â | Â | Â | Â |
 | a | 104 | 1 | - |  |  |
 | 1 | 26 | 1.40 (0.68-3.21) | 0.32 |  |  |
Tumor grade (2004 WHO) | Â | Â | Â | 0.14 | Â | Â |
 | PUNLMP | 13 | 1 | - |  |  |
 | LG | 84 | 1.41 (0.50-4.00) | 0.57 |  |  |
 | HG | 33 | 2.17 (0.70-5.56) | 0.2 |  |  |
Concomitant CIS | Â | Â | Â | Â | Â | Â |
 | absent | 123 | 1 | - |  |  |
 | present | 7 | 1.32 (0.36-5.28) | 0.20 |  |  |
Lymphovascular involvement | Â | Â | Â | Â | Â | Â |
 | absent | 110 | 1 | - |  |  |
 | present | 20 | 1.75 (0.86-4.93) | 0.11 |  |  |
Endophytic growth pattern | Â | Â | Â | Â | Â | Â |
 | absent | 90 | 1 | - |  |  |
 | present | 40 | 0.76 (0.39-1.52) | 0.45 |  |  |
von Brunn's nest involvement | Â | Â | Â | Â | Â | Â |
 | absent | 125 | 1 | - |  |  |
 | present | 5 | 1.54 (0.29-9.94) | 0.54 |  |  |
Multiplicity | Â | Â | Â | Â | Â | Â |
 | solitary | 70 | 1 | - | 1 | - |
 | multiple | 60 | 1.91 (1.04-3.59) | 0.038 | 1.93 (0.98-3.79) | 0.058 |
Tumor diameter (cm) | Â | Â | Â | Â | Â | Â |
 | < 3 | 99 | 1 | - | 1 | - |
 | ≥ 3 | 31 | 2.04 (1.13-5.06) | 0.023 | 2.10 (1.04-4.27) | 0.040 |
Intravesical therapy | Â | Â | Â | Â | Â | Â |
 | None | 55 | 1 | - | 1 | - |
 | BCG | 67 | 0.53 (0.23-0.96) | 0.039 | 0.35 (0.18-0.71) | 0.004 |
 | Anthracyclines | 8 | 0.96 (0.28-3.21) | 0.94 | 0.63 (0.24-2.38) | 0.63 |