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Table 3 Univariate and multivariate analysis for disease progression

From: Clinical significance of subepithelial growth patterns in non-muscle invasive bladder cancer

Variables

Cases (n)

Disease progression

   

Univariate

Multivariate

   

Hazard ratio (95% CI)

p value

Hazard ratio (95% CI)

p value

T stage

      
 

a

104

1

-

1

-

 

1

26

20.69 (7.82-446.23)

< 0.0001

20.94 (2.44-179.45)

0.006

Tumor grade (2004 WHO)

      
 

PUNLMP/LG

97

1

-

1

-

 

HG

33

14.37 (3.25-126.40)

0.0013

2.97 (0.098-90.16)

0.53

Concomitant CIS

      
 

absent

123

1

-

  
 

present

7

ND

0.51

  

Lymphovascular involvement

      
 

absent

110

1

-

1

-

 

present

20

12.07 (7.49-733.68)

0.0002

1.23 (0.13-11.28)

0.86

Multiplicity

      
 

solitary

70

1

-

  
 

multiple

60

5.44 (0.84-20.60)

0.082

  

Tumor diameter (cm)

      
 

< 3

99

1

-

1

-

 

≥ 3

31

16.93 (4.63-209.78)

0.0004

6.77 (0.69-66.8)

0.10

Endophytic growth pattern

      
 

absent

90

1

-

  
 

present

40

ND

0.096

  

von Brunn's nest involvement

      
 

absent

125

1

-

  
 

present

5

5.82 (0.74-5617.98)

0.068

  

Intravesical therapy

      
 

None

55

1

-

  
 

BCG

75

1.09 (0.20-5.99)

0.92

 Â