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Figure 3 | BMC Urology

Figure 3

From: Phosphatidylinositol 3'-kinase, mTOR, and Glycogen synthase kinase-3β mediated regulation of p21 in human urothelial carcinoma cells

Figure 3

Induction of p21 is partially dependent on mTOR. (A) UMUC-3 cells were serum starved for 24 hours and then stimulated with 10 ng/ml EGF in the presence or absence of 1 hour pretreatment with 12.5 nM rapamycin. S6 phosphorylation at serines 235/236 was also measured to verify rapamycin-mediated inhibition of mTOR. (B) Quantitation of relative p21 induction by EGF in the presence of absence of rapamycin in UMUC- and UMUC-14 cells. Error bars represent S.E.M.

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BMC Urology

ISSN: 1471-2490

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