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Figure 6 | BMC Urology

Figure 6

From: Phosphatidylinositol 3'-kinase, mTOR, and Glycogen synthase kinase-3β mediated regulation of p21 in human urothelial carcinoma cells

Figure 6

Proteasome inhibition causes an increase in p21. (A) UMUC-3 cells were serum starved for 24 hours and then treated with 1 μM and 10 μM MG-132 over a 180 minute time course. Cells were lysed and immunoblotted for p21 and tubulin. (B) Quantitation of relative p21 levels normalized to tubulin after 180 minutes treatment with 1 μM MG-132 is shown for UMUC-3 and UMUC-14 cells. Four replicates were tested. Error bars represent S.E.M.

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