Table 3 Multivariable Cox regression analysis identified an elevated CAV1 staining value in the tumor cytoplasm as an independent predictor of tumor specific survival.
From: Caveolin 1 protein expression in renal cell carcinoma predicts survival
CAV1 expression in the tumor cell cytoplasm | CAV1 expression in the tumor cell membrane | |||
|---|---|---|---|---|
Variable | HR (95% CI) | p-value | HR (95% CI) | p-value |
Age | 1.01 (0.99-1.01) | 0.35 | 1.01 (0.98-1.03) | 0.71 |
Sex | 0.45 | 0.44 | ||
female | 1 (Reference) | 1 (Reference) | ||
male | 1.26 (0.70-2.28) | 1.27 (0.69-2.23) | ||
T-Stage | 0.43 | 0.19 | ||
pT1 | 1 (Reference) | 1 (Reference) | ||
pT2 | 1.43 (0.19-10.86) | 0.73 | 1.43 (0.19-10.92) | 0.73 |
pT3 | 2.28 (0.30-17.58) | 0.43 | 2.64 (0.35-20.28) | 0.35 |
pT4 | 2.97 (0.27-33.25) | 0.38 | 3.39 (0.30-37.89) | 0.32 |
Metastatic disease | < 0.001 | < 0.001 | ||
N/M0 | 1 (Reference) | 1 (Reference) | ||
N/M+ | 5.04 (2.66-9.54) | 4.88 (2.60-9.16) | ||
Differentiation | < 0.001 | < 0.001 | ||
G1 | 1 (Reference) | 1 (Reference) | ||
G2 | 2.75 (1.07-7.10) | 0.04 | 2.55 (0.99-6.55) | 0.05 |
G3/4 | 12.02 (3.54-40.85) | < 0.001 | 12.29 (3.60-41.98) | < 0.001 |
CAV1 expression level | 0.03 | 0.34 | ||
≤ median | 1 (Reference) | 1 (Reference) | ||
> median | 1.95 (1.08-3.51) | 1.31 (0.75-2.30) | ||