Figure 2

(a) Receiver operating characteristic (ROC) curves for urinary IL-8, MMP-9, Syndecan and BTA. Based on the area under the ROC curve (AUROC), Youden Index cutoff values that maximized the sum of sensitivity and specificity were determined for each biomarker (crossed square on curve). Table provides performance values for each biomarker. PPV, positive predictive value. NPV, negative predictive value. (b) Receiver operating characteristic (ROC) curves for the combination of IL-8, MMP-9 and Syndecan. Based on the area under the ROC curve (AUROC), Youden Index cutoff values that maximized the sum of sensitivity and specificity were determined for combination of IL-8, MMP-9 and Syndecan. Table provides performance values for each biomarker. PPV, positive predictive value. NPV, negative predictive value.