Alterations of global histone H4K20 methylation during prostate carcinogenesis

BMC Urology

Table 3 Global H4K20 methylation levels are correlated to adverse clinical-pathological parameters

	H4K20me1	H4K20me2	H4K20me3
preoperative PSA†	p = 0.122	p = 0.573	p = 0.151
pT-stage	p = 0.122	p = 0.573	p = 0.157
capsular penetration	p = 0.094	p = 0.469	p = 0.902
seminal vesicle infiltration	p = 0.127	p = 0.947	p = 0.468
lymph node metastases	p = 0.002	p = 0.196	p = 0.091
Gleason Score‡	p = 0.191	p = 0.021	p = 0.074

† categorized: PSA < 4 ng/ml, 4-10 ng/ml, > 10 ng/ml; ‡ categorized: Gleason Sum ≤ 6, 7, ≥ 8

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