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Table 1 Determinants of Gleason score undergrading between biopsy and prostatectomy

From: Importance and determinants of Gleason score undergrading on biopsy sample of prostate cancer in a population-based study

  Total Cases Controls Univariate OR1(95% CI) p-value Multi-adjusted OR1,2(95% CI) p-value
  (n = 371) (n = 95) (n = 276)     
Age at diagnosis years (in continuous )     1.04 (1.00-1.08) 0.049 1.04 (1.00-1.09) 0.038
Socioeconomic status        
  High 128 31 97 1.00    
  Middle 155 43 112 1.20 (0.70-2.05) 0.502   
  Low 82 20 62 1.01 (0.53-1.93) 0.977   
  Unknown 6 1 5 0.63 (0.07-5.56) 0.674   
Sector of care        
  Private 235 48 187 1.00    
  Public 136 47 89 2.06 (1.28-3.31) 0.003   
PSA value        
  <10 242 63 179 1.00    
  10-20 39 14 25 1.59 (0.78-3.25) 0.203   
  >20 12 4 8 1.42 (0.41-4.88) 0.577   
  Unknown 78 14 64 0.62 (0.33-1.19) 0.149   
Clinical stage        
  T1-T2 272 61 211 1.00   1.00  
  T3-T4 93 33 60 1.90 (1.14-3.17) 0.014 1.81 (1.06-3.10) 0.030
  Tx 6 1 5 0.69 (0.08-6.03) 0.739 0.58 (0.06-5.37) 0.628
Number of biopsy cores        
  ≤ 9 175 56 119 2.02 (1.24-3.28) 0.005 1.93 (1.16-3.22) 0.011
  10 + 185 35 150 1.00   1.00  
  Unknown 11 4 7 2.45 (0.68-8.83) 0.171 2.65 (0.70-10.0) 0.151
Prostate volume cm3 (in continous)     0.99 (0.97-1.00) 0.031   
Number of procedures performed by the biopsy operator        
  1-29 110 37 73 1.75 (1.07-2.87) 0.026   
  30+ 254 57 197 1.00    
  Unknown 7 1 6 0.58 (0.07-4.88) 0.613   
Delay between biopsy and prostatectomy days (in continous)     1.01 (1.00-1.01) 0.004 1.01 (1.00-1.01) 0.018
  1. 1) OR: Odds Ratio derived from logistic regression considering as cases patients whose biopsy Gleason score was lower than the prostatectomy Gleason score and as controls everybody else, 2) Simultaneously adjusted for age, pathological stage, number of biopsy cores and delay between the two procedures.