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Table 1 Determinants of Gleason score undergrading between biopsy and prostatectomy

From: Importance and determinants of Gleason score undergrading on biopsy sample of prostate cancer in a population-based study

 

Total

Cases

Controls

Univariate OR1(95% CI)

p-value

Multi-adjusted OR1,2(95% CI)

p-value

 

(n = 371)

(n = 95)

(n = 276)

    

Age at diagnosis years (in continuous )

   

1.04 (1.00-1.08)

0.049

1.04 (1.00-1.09)

0.038

Socioeconomic status

       

  High

128

31

97

1.00

   

  Middle

155

43

112

1.20 (0.70-2.05)

0.502

  

  Low

82

20

62

1.01 (0.53-1.93)

0.977

  

  Unknown

6

1

5

0.63 (0.07-5.56)

0.674

  

Sector of care

       

  Private

235

48

187

1.00

   

  Public

136

47

89

2.06 (1.28-3.31)

0.003

  

PSA value

       

  <10

242

63

179

1.00

   

  10-20

39

14

25

1.59 (0.78-3.25)

0.203

  

  >20

12

4

8

1.42 (0.41-4.88)

0.577

  

  Unknown

78

14

64

0.62 (0.33-1.19)

0.149

  

Clinical stage

       

  T1-T2

272

61

211

1.00

 

1.00

 

  T3-T4

93

33

60

1.90 (1.14-3.17)

0.014

1.81 (1.06-3.10)

0.030

  Tx

6

1

5

0.69 (0.08-6.03)

0.739

0.58 (0.06-5.37)

0.628

Number of biopsy cores

       

  ≤ 9

175

56

119

2.02 (1.24-3.28)

0.005

1.93 (1.16-3.22)

0.011

  10 +

185

35

150

1.00

 

1.00

 

  Unknown

11

4

7

2.45 (0.68-8.83)

0.171

2.65 (0.70-10.0)

0.151

Prostate volume cm3 (in continous)

   

0.99 (0.97-1.00)

0.031

  

Number of procedures performed by the biopsy operator

       

  1-29

110

37

73

1.75 (1.07-2.87)

0.026

  

  30+

254

57

197

1.00

   

  Unknown

7

1

6

0.58 (0.07-4.88)

0.613

  

Delay between biopsy and prostatectomy days (in continous)

   

1.01 (1.00-1.01)

0.004

1.01 (1.00-1.01)

0.018

  1. 1) OR: Odds Ratio derived from logistic regression considering as cases patients whose biopsy Gleason score was lower than the prostatectomy Gleason score and as controls everybody else, 2) Simultaneously adjusted for age, pathological stage, number of biopsy cores and delay between the two procedures.