Prognostic value of changes in quality of life scores in prostate cancer

BMC Urology

Table 5 Change in QoL measures and associated HRs for death

Change variable	QoL change mean (SD)	Univariate		Multivariate
		HR (95% CI)	P	HR (95% CI)	P
General quality of life
Global	−1.9 (28.3)	1.01 (0.90 – 1.12)	0.80	0.96 (0.85 – 1.07)	0.46
General function
Physical	−2.0 (22.7)	1.10 (0.98 – 1.23)	0.09	1.15 (0.93 – 1.37)	0.19
Role	−4.3 (33.4)	1.07 (0.99 – 1.16)	0.09	0.92 (0.75 – 1.08)	0.31
Emotional	3.8 (25.2)	0.95 (0.84 – 1.06)	0.36	0.91 (0.71 – 1.12)	0.39
Cognitive	1.1 (24.6)	0.92 (0.80 – 1.04)	0.16	0.76 (0.54 – 0.98)	0.04*
Social	−1.6 (31.9)	1.06 (0.97 – 1.15)	0.19	1.03 (0.87 – 1.20)	0.71
General symptom
Fatigue	2.8 (29.7)	0.94 (0.84 – 1.05)	0.28	0.97 (0.94 – 1.20)	0.77
Nausea/Vomiting	2.8 (22.3)	0.95 (0.82 – 1.08)	0.45	0.77 (0.56 – 1.03)	0.06
Pain	0.6 (31.0)	0.94 (0.84 – 1.04)	0.24	0.91 (0.73 – 1.09)	0.34
Dyspnea	1.2 (26.7)	1.09 (0.98 – 1.19)	0.09	1.16 (1.02 – 1.30)	0.02*
Insomnia	−2.5 (34.0)	0.96 (0.87 – 1.05)	0.36	0.92 (0.79 – 1.04)	0.19
Appetite loss	0.9 (28.2)	1.01 (0.90 – 1.12)	0.82	1.03 (0.87 – 1.20)	0.68
Constipation	0.6 (25.6)	0.94 (0.82 – 1.05)	0.28	0.97 (0.82 – 1.12)	0.69
Diarrhea	2.0 (25.5)	0.99 (0.87 – 1.11)	0.88	0.94 (0.80 – 1.08)	0.38
Financial	3.4 (34.9)	1.0 (0.91 – 1.08)	0.93	1.08 (0.97 – 1.20)	0.17

• HRs correspond to a 10-point increment for QoL scores.
• 2 sets of multivariate models were constructed: one for global QoL and other for all general function and symptom variables combined.
• Multivariate model (for change in general function and symptom variables combined) adjusted for prior treatment history, stage at diagnosis and all QoL change variables.
• Multivariate model for change in global QoL adjusted for prior treatment history and stage at diagnosis.
*P <0.05.

ISSN: 1471-2490