Patient | Daptomycin dosing | Daptomycin treatment duration | Concomitant antibiotics | Posttreatment urine culture |
---|---|---|---|---|
Normal kidney function | ||||
1 | 7.5 mg/kg q24h | 7 days | None | VRE eradicated |
2 | 8 mg/kg q24h | 3 days | None | VRE eradicated |
3 | 13 mg/kg q24h* | 10 days | None | VRE eradicated |
Mild kidney disease (CKD 2) | ||||
4 | 5 mg/kg q24h | 3 days | Fluconazole | VRE eradicated |
5 | 5 mg/kg q24h | 3 days | None | VRE eradicated |
Moderate kidney disease (CKD 3) | ||||
6 | 5 mg/kg q24h | 3 days | None | VRE eradicated |
7 | 5 mg/kg q24h | 3 days | Gentamicin 120 mg once a day | 5 days after initiation of daptomycin; VRE eradicated |
8 | 5 mg/kg q24h | 3 days | None | VRE eradicated |
Severe kidney disease/kidney failure (CKD 4–5) | ||||
9 | 5 mg/kg q24h† | 3 days | None | VRE eradicated |
10 | 5 mg/kg q48h | 3 days | None | VRE eradicated; patient died 2 days later (not related to infection) |