Figure 2From: The effect of indomethacin on the muscarinic induced contractions in the isolated normal guinea pig urinary bladder Pressure changes and instantaneous frequency plot of an isolated guinea pig bladder induced by arecaidine. A. Pressure changes of an isolated guinea pig bladder induced by 1 ÎĽM arecaidine. The average frequency in the initial phase, defined as the first 2 minutes after arecaidine application, is labelled Fini. The steady state frequency (Fsteady) is defined as the average frequency over a 5 minutes period prior to the wash out. B. Instantaneous frequency plot of an isolated guinea pig bladder. The time of stimulation with 1 ÎĽM arecaidine is indicated with an arrow. The frequency of the autonomous contractions initially increases and then return back to a lower steady level after approximately 5 minutes.Back to article page