Figure 4From: The effect of indomethacin on the muscarinic induced contractions in the isolated normal guinea pig urinary bladder Timeline, pressure changes and instantaneous frequency plot of an isolated guinea pig bladder pre-exposed to indomethacin before stimulation with arecaidine. A. an outline of the experiment. After the first 1 ÎĽM arecaidine simulation (enlarged in panel B as 1), the organ bath is washed to remove the arecaidine. After 15 minutes, 10 ÎĽM indomethacin is added followed by a second stimulation of arecaidine (enlarged in panel B as 2). After a wash step, a third arecaidine stimulation is performed (enlarged in panel B as 3). B. Parts of panel A in an expanded scale. C. Instantaneous frequency plot comparing the three conditions described in panel A.Back to article page