Table 1 Demographic and clinicopathologic characteristics for subjects in each stage of the multi-stage design
From: ANKS1B is a smoking-related molecular alteration in clear cell renal cell carcinoma
| Ā | Affymetrix microarray | RT-PCR | |||||||
|---|---|---|---|---|---|---|---|---|---|
Stage 1: non-obese subjects | Stage 2: obese subjects | Stage 3: non-obese subjects | |||||||
Non-smokers 30 (65%) | Smokers 16 (35%) | p-value | Non-smokers 12 (63%) | Smokers 7 (37%) | p-value | Non-smokers 54 (66%) | Smokers 28 (34%) | p-value | |
Gender | Ā | Ā | 0.2170 | Ā | Ā | 0.1698 | Ā | Ā | 0.0273 |
āMale | 14 (47%) | 11 (69%) | Ā | 4 (33%) | 5 (71%) | Ā | 30 (56%) | 23 (82%) | Ā |
āFemale | 16 (53%) | 5 (31%) | Ā | 8 (67%) | 2 (29%) | Ā | 24 (44%) | 5 (18%) | Ā |
Age at surgery | Ā | Ā | 0.2537 | Ā | Ā | 0.8584 | Ā | Ā | 0.4597 |
ā<50 | 3 (10%) | 3 (19%) | Ā | 2 (17%) | 1 (14%) | Ā | 9 (17%) | 5 (18%) | Ā |
ā50-79 | 24 (80%) | 13 (81%) | Ā | 9 (75%) | 6 (86%) | Ā | 41 (76%) | 23 (82%) | Ā |
āā„80 | 2 (7%) | 0 | Ā | 1 (8%) | 0 | Ā | 4 (7%) | 0 | Ā |
āUnknown | 1 (3%) | 0 | Ā | 0 | 0 | Ā | 0 | 0 | Ā |
Nuclear grade | Ā | Ā | 0.2032 | Ā | Ā | 0.5834 | Ā | Ā | 0.2000 |
ā1 | 3 (10%) | 1 (6%) | Ā | 4 (33%) | 2 (29%) | Ā | 5 (9%) | 3 (11%) | Ā |
ā2 | 18 (60%) | 7 (44%) | Ā | 8 (67%) | 4 (57%) | Ā | 17 (32%) | 7 (25%) | Ā |
ā3 | 9 (30%) | 8 (50%) | Ā | 0 | 1 (14%) | Ā | 24 (44%) | 11 (39%) | Ā |
ā4 | 0 | 0 | Ā | 0 | 0 | Ā | 8 (15%) | 7 (25%) | Ā |
Pathologic tumor stage | Ā | Ā | 0.0123 | Ā | Ā | 0.5926 | Ā | Ā | 0.4713 |
āpT1 | 24 (80%) | 7 (44%) | Ā | 9 (75%) | 6 (86%) | Ā | 31 (57%) | 11 (39%) | Ā |
āpT2 | 2 (7%) | 2 (12%) | Ā | 2 (17%) | 1 (14%) | Ā | 4 (7%) | 4 (14%) | Ā |
āpT3 | 4 (13%) | 7 (44%) | Ā | 1 (8%) | 0 | Ā | 18 (33%) | 13 (46%) | Ā |
āpT4 | 0 | 0 | Ā | 0 | 0 | Ā | 1 (2%) | 0 | Ā |
Presence of necrosis | Ā | Ā | 0.2829 | Ā | Ā | 1.0000 | Ā | Ā | 0.4739 |
āYes | 5 (17%) | 5 (31%) | Ā | 1 (8%) | 1 (14%) | Ā | 19 (35%) | 13 (46%) | Ā |
āNo | 25 (83%) | 11 (69%) | Ā | 11 (92%) | 6 (86%) | Ā | 34 (63%) | 15 (54%) | Ā |
āUnknown | 0 | 0 | Ā | 0 | 0 | Ā | 1 (2%) | 0 | Ā |