- Case report
- Open Access
- Open Peer Review
Hem-O-Lok clip: a neglected cause of severe bladder neck contracture and consequent urinary incontinence after robot-assisted laparoscopic radical prostatectomy
© Cormio et al.; licensee BioMed Central Ltd. 2014
- Received: 27 August 2013
- Accepted: 11 February 2014
- Published: 20 February 2014
Hem-o-lok clips are widely used during robot-assisted and laparoscopic radical prostatectomy to control the lateral pedicles. There are a few reports of hem-o-lok clip migration into the bladder or vesico-urethral anastomosis and only four cases of hem-o-lok clip migration resulting into bladder neck contracture. Herein, we describe the first case, to our knowledge, of hem-o-lok clip migration leading to severe bladder neck contracture and subsequent stress urinary incontinence.
A 62-year-old Caucasian man underwent robot-assisted laparoscopic radical prostatectomy for a T1c Gleason 8 prostate cancer. One month after surgery the patient was fully continent; however, three months later, he presented with acute urinary retention requiring suprapubic drainage. Urethroscopy showed a hem-o-lok clip strongly attached to the area between the vesico-urethral anastomosis and the urethral sphincter and a severe bladder neck contracture behind it. Following cold-knife urethral incision and clip removal, the bladder neck contracture was widely resected. At 3-month follow-up, the patient voided spontaneously with a peak flow rate of 9.5 ml/sec and absence of post-void residual urine, but leaked 240 ml urine at the 24-hour pad test. To date, at 1-year follow-up, his voiding situation remains unchanged.
The present report provides further evidence for the risk of hem-o-lok clip migration causing bladder neck contracture, and is the first to demonstrate the potential of such complication to result into stress urinary incontinence.
- Foreign body
Hem-o-lok® clips (Weck Surgical Instruments, Teleflex Medical, Durham, NC) are widely used during laparoscopic radical prostatectomy for controlling the lateral pedicles. Their migration into the urinary tract has already been described [1–7], presenting with spontaneous expulsion, urethral erosion, bladder stone formation and even bladder neck contracture (BNC). There is no previous report of stress urinary incontinence (SUI) following removal of a migrated hem-o-lok clip. Herein we present the first case of hem-o-lok clip migration into the vesico-urethral anastomosis leading to severe bladder neck contracture (BNC) and subsequent SUI.
The vesico-urethral anastomosis represents a potential site for clip migration. Palou et al.  reported migration of a metal clip after retropubic radical prostatectomy (RRP) presenting with perineal pain; Long et al.  reported migration of a metal clip after RRP causing BNC. Yi et al.  recently reported 4 further cases of metal clip migration after RRP; two resulted in stone formation and the other two into BNC. There are few reports of hem-o-lok clip migration into the urinary tract leading to spontaneous expulsion, urethral erosion, bladder stone formation and bladder neck contracture [1–7]. These findings would suggest that the use of clips in proximity of the vesico-urethral anastomosis should be limited if not avoided, and that the occurrence of de novo voiding symptoms in patients having undergone radical prostatectomy should rise the suspect of clip-related complications. Specifically, our patient was continent one month after surgery but developed de novo urinary retention two months later.
BNC represents an uncommon yet unpleasant clip-related complication. BNC following hem-o-lok clip migration was first described by Blumenthal et al ; in their series of 524 RALPs, 2 patients (0.4%) had a hem-o-lok clip-related BNC. The first, dealt with clip removal and KTP laser vaporization of the stricture, ended up to be continent but on self-catheterization to prevent stricture recurrence; the second, dealt with clip removal and transurethral incision with steroid injection, also ended up on self catheterization to prevent stricture recurrence yet used 1 pad/day for an undefined form of incontinence. More recently, Yi et al.  reported hem-o-lok clip-related BNC in 2 (1.3%) of the 153 patients they treated with RALP. Both cases were successfully managed by clip removal and a single urethral dilatation; both did not require self-catheterization and ended up in no recurrence nor urinary leak.
Our case had to be dealt with cold-knife urethral incision to remove the clip, and wide bladder neck resection. It is difficult to establish whether incontinence was due to a too large resection of the stricture causing an accidental injure to the sphincter or the sphincteric function having been jeopardised by a fibrotic reaction to the presence of the clip itself, as suggested by the whitish appearance of the urethral sphincter at 12-o-clock position. Whatever the case, our patient did not require self catheterization to prevent recurrence but developed urinary incontinence that was made even more bothersome by the fact that he had regained continence already one month after radical prostatectomy.
The present case provides further evidence for the risk of hem-o-lok clip migration causing BNC and is the first to demonstrate the potential of such complication to result into stress urinary incontinence with its unpleasant consequences.
Written informed consent was obtained from the patient for publication of this Case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.
The authors declare no acknowledgment.
- Blumenthal K, Sutherland D, Wagner K, Frazier HA, Engel JD: Bladder neck contractures related to the use of Hem-o-Lok clips in robot-assisted laparoscopic radical prostatectomy. Urology. 2008, 72: 158-161. 10.1016/j.urology.2007.11.105.View ArticlePubMedGoogle Scholar
- Tunnard GJ, Biyani CS: An unusual complication of a Hem-o-Lok Clip® following laparoscopic radical prostatectomy. J Laparoendosc Adv Surg Tech A. 2009, 19: 649-651. 10.1089/lap.2009.0145.View ArticlePubMedGoogle Scholar
- Moser RL, Narepalem N: Erosion of Hem-o-Lok clips at the bladder neck after robot-assisted radical prostatectomy. J Endourol. 2009, 23: 949-951. 10.1089/end.2007.0328.View ArticlePubMedGoogle Scholar
- Tugcu V, Polat H, Ozbay B, Eren GA, Tasci AI: Stone formation from intravesical Hem-o-lok clip migration after laparoscopic radical prostatectomy. J Endourol. 2009, 23: 1111-1113. 10.1089/end.2008.0633.View ArticlePubMedGoogle Scholar
- Banks EB, Ramani A, Monga M: Intravesical Weck clip migration after laparoscopic radical prostatectomy. Urology. 2008, 71: 351-View ArticlePubMedGoogle Scholar
- Mora ER, Galí OB, Garin JA, Arango O: Intravesical migration and spontaneous expulsion of a Hem-o-lok polymer ligating clip after laparoscopic radical prostatectomy. Urology. 2010, 75: 1317-10.1016/j.urology.2009.06.062.View ArticlePubMedGoogle Scholar
- Pereira Arias JG, Gamarra Quintanilla M, Leibar Tamayo A, Astobieta Odriozola A, Ibarluzea González G: Complications and incidences in our first 250 robotic radical prostatectomies. Actas Urol Esp. 2010, 34: 428-439.View ArticlePubMedGoogle Scholar
- Palou J, Alberola JM, Villavicencio H, Vicente J: It’s like a pain in the … perineum: a surgical clip protruding into the urethra through the urethrovesical anastomosis after radical prostatectomy. Scand J Urol Nephrol. 1997, 31 (5): 493-495. 10.3109/00365599709030649.View ArticlePubMedGoogle Scholar
- Long B, Bou S, Bruyere F, Lanson Y: Vesico-urethral anastomotic stricture after radical prostatectomy secondary to migration of a metal clip. Prog Urol. 2006, 16: 384-385.PubMedGoogle Scholar
- Yi JS, Kwak C, Kim HH, Ku JH: Surgical clip-related complications after radical prostatectomy. Korean J Urol. 2010, 51 (10): 683-687. 10.4111/kju.2010.51.10.683.View ArticlePubMedPubMed CentralGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2490/14/21/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.