A combined index to classify prognostic comorbidity in candidates for radical prostatectomy

BMC Urology

Table 3 Multivariate analysis: optimal Cox proportional hazard models for two-sided and three-sided stratifications

Optimal model, 2-sided stratifications
Category	Hazard ratio	95% confidence interval	p
Age (per year)	1.06	1.04-1.08	<0.0001
Gleason score 8+	2.25	1.74-2.90	<0.0001
pN1	1.70	1.24-2.34	0.0010
ASA 3	1.58	1.17-2.12	0.0030
Charlson score 2+	1.71	1.27-2.30	0.0004
Body mass index 30+ kg/m²	1.47	1.10-1.95	0.0080
Optimal model, 3-sided stratifications
Category	Hazard ratio	95% confidence interval	p
Age (per year)	1.06	1.03-1.08	<0.0001
Gleason score 7	1.07	0.80-1.43	0.6641
Gleason score 8+	2.21	1.63-3.00	<0.0001
ASA 2	1.84	1.10-3.07	0.0202
ASA 3	2.69	1.50-4.83	0.0009
Charlson score 1	1.24	0.93-1.66	0.1412
Charlson score 2+	1.79	1.29-2.47	0.0004
pT3-4 and pN0	1.07	0.81-1.42	0.6420
pN1	1.85	1.30-2.62	0.0006
Body mass index 30–34.9 kg/m²	1.37	1.02-1.84	0.0385
Body mass index 35+ kg/m²	1.95	0.94-4.02	0.0718

Reference categories were other patients in the case of two-sided comparisons and the lowest risk category when two-sided comparisons were used.

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