Table 2 Relative risks of death from disease and overall death within 5 years according to clinicopathological factors and ezrin expression in two independent patient cohorts
Cohort I | Cohort II | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Risk of death within 5 years | Risk of death from disease | Risk of death within 5 years | |||||||
Unadjusted | Adjusted | Unadjusted | Adjusted | Unadjusted | Adjusted | ||||
n (events) | HR (95% CI) | HR (95% CI) | n (events) | HR (95% CI) | HR (95% CI) | n (events) | HR (95% CI) | HR (95% CI) | |
Age | |||||||||
Continuous | 100(46) | 1.05(1.02-1.08) | 1.05(1.02-1.08) | 300(100) | 1.05(1.03-1.07) | 1.05(1.02-1.07) | 342(170) | 1.06(1.05-1.08) | 1.07(1.05-1.08) |
Gender | |||||||||
Female | 25(11) | 1.00 | 1.00 | 71(28) | 1.00 | 1.00 | 82(40) | 1.00 | 1.00 |
Male | 75(35) | 0.96(0.49-1.89) | 1.12(0.54-2.31) | 227(72) | 0.79(0.51-1.22) | 1.03(0.66-1.61) | 260(130) | 0.97(0.68-1.38) | 1.20(0.83-1.72) |
Stage | |||||||||
Ta | 41(7) | 1.00 | 1.00 | 104(13) | 1.00 | 1.00 | 115(35) | 1,00 | 1.00 |
T1 | 22(15) | 5.06(2.06-12.46) | 2.20(0.73-6.68) | 97(25) | 2.20(1.13-4.31) | 2.17(1.11-4.25) | 116(53) | 1.63(1.06-2.50) | 1.57(1.02-2.40) |
T2-4 | 37(24) | 6.15(2.64-14.31) | 2.44(0.73-8.19) | 97(62) | 8.86(4.86-16.16) | 8.70(4.76-15.89) | 111(82) | 4.34(2.91-6.46) | 4.36(2.92-6.52) |
Grade | |||||||||
Low | 44(9) | 1.00 | 1.00 | 75(7) | 1.00 | 1.00 | 82(20) | 1.00 | 1.00 |
High | 56(37) | 4.71(2.27-9.79) | 2.94(1.32-6.53) | 223(93) | 5.75(2.66-12.39) | 1.67(0.64-4.35) | 260(150) | 3.09(1.94-4.93) | 1.20(0.67-2.13) |
Ezrin expression* | |||||||||
High | 59(19) | 1.00 | 1.00 | 136(27) | 1.00 | 1.00 | 120(40) | 1.00 | 1.00 |
Low | 41(27) | 3.09(1.71-5.58) | 1.99(1.05-3.77) | 162(73) | 2.77(1.78-4.31) | 1.23(0.75-2.02) | 222(130) | 2.15(1.51-3.06) | 1.24(0.84-1.84) |