Figure 1From: Panobinostat synergizes with bortezomib to induce endoplasmic reticulum stress and ubiquitinated protein accumulation in renal cancer cells The combination of panobinostat and bortezomib inhibited renal cancer growth effectively. A, MTS assay results (mean ± SD, n = 6) after cells were treated for 48 hours either with bortezomib or panobinostat alone or with bortezomib and panobinostat together. B, Colony formation assay results (mean ± SD, n = 3) after 1–2 week incubation in control media (C) or media containing 50 nM panobinostat (P) and/or 10 nM bortezomib (B). *p = 0.0495; **p = 0.0463.Back to article page