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Figure 2 | BMC Urology

Figure 2

From: Panobinostat synergizes with bortezomib to induce endoplasmic reticulum stress and ubiquitinated protein accumulation in renal cancer cells

Figure 2

The combination of panobinostat and bortezomib suppressed tumor growth in vivo. A murine subcutaneous tumor model was made using Caki-1 cells, and the control group received intraperitoneal injections of DMSO, while other groups received either panobinostat (2 mg/kg) or bortezomib (60 μg/kg) or both. Injections were given once a day, 5 days a week, for 2 weeks. The 10-day treatment was well tolerated and suppressed tumor growth significantly (mean ± SE; p = 0.0283 at day 12).

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BMC Urology

ISSN: 1471-2490

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