Figure 5

Histone acetylation was a consequence of ubiquitinated protein accumulation. A, 48-hour treatment with panobinostat caused dose-dependent histone acetylation in all the cell lines but did not cause ubiquitinated protein accumulation. B, 48-hour treatment with bortezomib, on the other hand, caused both histone acetylation and ubiquitinated protein accumulation in Caki-1 and ACHN cells and caused only ubiquitinated protein accumulation in 769-P cells.