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Figure 5 | BMC Urology

Figure 5

From: Panobinostat synergizes with bortezomib to induce endoplasmic reticulum stress and ubiquitinated protein accumulation in renal cancer cells

Figure 5

Histone acetylation was a consequence of ubiquitinated protein accumulation. A, 48-hour treatment with panobinostat caused dose-dependent histone acetylation in all the cell lines but did not cause ubiquitinated protein accumulation. B, 48-hour treatment with bortezomib, on the other hand, caused both histone acetylation and ubiquitinated protein accumulation in Caki-1 and ACHN cells and caused only ubiquitinated protein accumulation in 769-P cells.

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