Table 2 Comparison of clinicopathological factors for RCC patients diagnosed with and without synchronous metastases (SMs) in Iceland, 1971–2005
N | SM (%) | Without SM (%) | p-value* | |
|---|---|---|---|---|
Mean age | 794 | 65 (±13) | 65 (±13) | 0.87 |
Gender | ||||
Male | 481 | 137 (29) | 344 (71) | 0.81 |
Female | 313 | 87 (28) | 226 (72) | |
Year of diagnosis | < 0.001 | |||
1971–1975 | 65 | 23 (35) | 45 (65) | |
1976–1980 | 65 | 22 (36) | 41 (64) | |
1981–1985 | 92 | 36 (39) | 56 (61) | |
1986–1990 | 103 | 40 (38) | 64 (62) | |
1991–1995 | 127 | 32 (25) | 95 (75) | |
1996–2000 | 139 | 25 (18) | 114 (82) | |
2001–2005 | 202 | 44 (22) | 158 (78) | |
Diagnosis | < 0.001 | |||
Incidental | 236 | 14 (6) | 222 (94) | |
Symptomatic | 558 | 207 (37) | 351 (63) | |
Laterality** | < 0.001 | |||
Right kidney | 427 | 94 (22) | 333 (78) | |
Left kidney | 359 | 122 (34) | 237 (66) | |
Mean ESR | 29.7 (±32) | 59.1 (±39) | < 0.001 | |
Tumor size by category | < 0.001 | |||
0.1–4.0 | 177 | 19 (11) | 158 (89) | |
4.1–7.0 | 252 | 64 (25) | 188 (75) | |
7.1–10.0 | 226 | 80 (35) | 146 (65) | |
10.1–13.0 | 76 | 35 (46) | 41 (54) | |
13.1–16.0 | 46 | 24 (53) | 22 (47) | |
> 16.0 | 17 | 10 (61) | 7 (39) | |
T stage | < 0.001 | |||
T1a | 154 | 6 (4) | 148 (94) | |
T1b | 140 | 12 (9) | 128 (91) | |
T2a | 92 | 16 (17) | 76 (82) | |
T2b | 51 | 14 (36) | 37 (64) | |
T3 | 328 | 125 (38) | 203 (62) | |
T4 | 30 | 11 (63) | 19 (47) | |
Histological RCC subtype | 0.13 | |||
Clear cell | 705 | 194 (28) | 511 (72) | |
Papillary | 65 | 14 (22) | 41 (78) | |
Chromophobe | 15 | 1 (7) | 14 (93) | |
Other | 9 | 3 (33) | 5 (66) | |
Nuclear grade | < 0.001 | |||
I - II | 449 | 66 (15) | 383 (85) | |
III - IV | 345 | 147 (43) | 198 (57) |