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Table 5 Significant differences in quality of life (QoL)

From: Intermittent versus continuous androgen deprivation for locally advanced, recurrent or metastatic prostate cancer: a systematic review and meta-analysis

Study

EORTC quality-of-life core questionnaire (QLQ-C30) and the EORTC Prostate Cancer Module

Crook 2012 [9, 10](CIC-CTG PR.7 Trial)

Intermittent (better): hot flashes, desire for sexual activity, and urinary symptoms

Continuous: -

Calais da Silva 2009/2011 [44, 45](SEUG Trial)

Intermittent (better): sexual function

Continuous (better): emotional domain, nausea and vomiting, severity of insomnia

Hussain 2013 [8, 55](SWOG 9346 Trial)

Intermittent (better): erectile function and mental health at 3 months but not thereafter

Continuous: -

Salonen 2012/2013 [11, 12](FinnProstate Trial VII)

Intermittent (better): sexual function

Continuous: -

Tunn 2012 [1, 46, 47](EC507 Trial)

Intermittent: NR

Continuous: NR

De Leval 2002 [51]

Intermittent: NR

Continuous: NR

Langenhuijsen 2008/2013 [52, 53] (TULP Trial)

Intermittent: NS

Continuous: NS

Miller 2007 [56]

Intermittent (better): sexual activity appeared to be favorable in the intermittent

Continuous: -

Mottet 2012 [50](TAP 22 Trial)

Intermittent: NS

Continuous: NS

Verhagen 2008/2013 [48, 49]

Intermittent (better): symptom and potency scales

Continuous: -

Hering 2000 [54]

Intermittent (better): erectile function

Continuous: -

Irani 2008 [57]

Intermittent (better): ability to have and maintain an erection.

Continuous: -

Silva 2013 [58](SEUG 9901 Trial)

Intermittent (better): sexual activity

 

Continuous: -

  1. Abbreviations: EORTC European Organization for Research and Treatment of Cancer, NS not significant, NR not reported.
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BMC Urology

ISSN: 1471-2490

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