Figure 4From: Intraprostatic injection of botulinum toxin type- A relieves bladder outlet obstruction in human and induces prostate apoptosis in dogsPhotomicrographs and terminal deoxynucleotidyl-mediated deoxyuridine triphosphate nick end labeling (TUNEL) staining of prostate sections after saline (A,B) and BTX-A (C,D) injection at 1 month. Significant glandular proliferation with papillary infolding in the lumen was seen in the control canine (A). Atrophy change of glandular component with flattening of the lining epithelium was seen in the BTX-A treated canine (C). Very few apoptotic nuclei are recognizable in the control animal (B). Strong fluorescence of apoptotic nuclei was seen in the BTX-A treated animal at 1 month. A, C magnification × 40; B, D magnification × 100.Back to article page