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Table 1 Plasma concentrations of MMP1, MMP2, MMP3, MMP9, TIMP1, TIMP2, the MMP1/TIMP1-complex (MTC1), and the ratio of MMP2/TIMP1 of healthy volunteers, of patients with non-metastasized (BCa) and metastasized (mBCa) TCC of the bladder.

From: Combined determination of plasma MMP2, MMP9, and TIMP1 improves the non-invasive detection of transitional cell carcinoma of the bladder

 

Controls (n = 79)

BCa (n = 57)

mBCa (n = 11)

MMP1 (μg/l)

5.6 (0.6–24.4)

2.8 (0.6–20.6)

* p < 0.001

4.4 (0.6–24.4)

*p > 0.05

+ p > 0.05

MMP2 (μg/l)

749 (547–1295)

1030 (406–3751)

* p < 0.001

1114 (820–2182)

* p < 0.001

+ p > 0.05

MMP3 (μg/l)

11.9 (0.18–34.9)

9.9 (0.3–37.4)

*p > 0.05

17.7 (0.6–27.9)

*p > 0.05

+ p > 0.05

MMP9 (μg/l)

19.4 (3.52–411)

22.9 (4.4–412)

*p > 0.05

56.3 (6.1–269)

*p > 0.05

+ p > 0.05

TIMP1 (μg/l)

423 (121–1776)

184 (57.8–1084)

* p < 0.001

300 (207–1029)

*p > 0.05

+ p > 0.05

TIMP2 (μg/l)

146 (91–374)

132 (24.9–424)

* p < 0.01

128 (76.0–335)

*p > 0.05

+ p > 0.05

MTC1 (μg/l)

30.5 (4.1–143)

24.8 (2.8–63.3)

*p > 0.05

30.3 (15.1–74.3)

*p > 0.05

+ p > 0.05

Ratio of MMP2/TIMP1

1.87 (0.47–7.37)

5.83 (0.87–23.3)

* p < 0.05

3.07 (1.02–9.56)

* p < 0.001

+ p > 0.05

  1. Key: TCC = transitional cell carcinoma of the bladder; MMP = matrix metalloproteinase; TIMP = tissue inhibitor of matrix metalloproteinase; MTC1 = MMP1/TIMP1-complex. Values are presented as median values with ranges (in parentheses). Statistical differences among the groups were calculated by the non-parametric Kruskal-Wallis test. Statistical significances of at least p < 0.05 are typed in 'bold'; comparisons are indicated by following symbols: *, between controls and BCa, as well as mBCa; +, between BCa and mBCa.