Table 4 Diagnostic sensitivities and specificities of MMPs, TIMPs, and the MMP1/TIMP1-complex (MTC1) as single markers and two- and three-marker combinations to distinguish between healthy persons and bladder cancer patients at the 95% limits of sensitivity and specificity, respectively.^a

Single marker

MMP1

   16.5

95 (85 – 98)

4.2 (1 – 12)

   0.95

24 (15 – 34)

95 (85 – 98)

MMP2

   613

95 (85 – 98)

7 (2 – 15)

   1071

47 (35 – 60)

95 (85 – 98)

MMP3

   25.2

95 (85 – 98)

3 (0.4 – 10)

   3.1

13 (6 – 24)

95 (85 – 98)

MMP9

   6.0

95 (85 – 98)

20 (11 – 31)

   106

12 (5 – 22)

95 (85 – 98)

TIMP1

   655

95 (85 – 98)

26 (16 – 38)

   158

38 (27 – 51)

95 (85 – 98)

TIMP2

   315

95 (85 – 98)

1.4 (0.2 – 7.4)

   112

40 (28 – 52)

95 (85 – 98)

MTC1

   57.3

95 (85 – 98)

12 (6 – 22)

   6.9

6 (2 – 15)

95 (85 – 98)

Marker combinations ^c

Ratio of MMP2 to TIMP1

   1.65

95 (85 – 98)

46 (34 – 58)

   5.45

49 (36 – 61)

95 (85 – 98)

mROC combinations^d

MMP9 + TIMP1

   -1.004

95 (85 – 98)

74 (62 – 84)

   -0.482

82 (70 – 90)

95 (85 – 98)

MMP9 + TIMP1 + MMP2

   0.745

95 (85 – 98)

94 (85 – 98)

   0.841

94 (85 – 98)

95 (85 – 98)