Figure 1

Indices of bladder inflammation using Evan's Blue extravasation as an experimental endpoint. Panel A presents group mean Evan's Blue concentration (μg/g) obtained 1, 4, 12, 24, or 48 hr after intravesical administration of 1% zymosan. Groups 4 hr 12 hr, and 24 hr did not differ from each other but were significantly greater than either groups 1 hr, 48 hr, naive control (open circle), and saline control (open triangle) as denoted by *. Panel B presents group mean Evan's Blue concentration obtained from rats receiving 0.1, 0.5, 1.0, or 2.0% intravesical zymosan administration 24 h previously. * denote significantly different from 0.1 and 0.5% groups. For all groups in A&B, N = 5. Error bars indicate SEM.