Drug use | Adjusted modela | Exclusive use modelb | ||||
---|---|---|---|---|---|---|
Controls N(%) | Cases N(%) | OR (95%CI)c | Controls N(%) | Cases N(%) | OR (95%CI)c | |
All NSAIDs | ||||||
Never | 278 (61.0) | 232 (63.4) | 1.0 (reference) | 249 (68.0) | 211 (74.6) | 1.0 (reference) |
Ever | 178 (39.0) | 134 (36.6) | 0.6 (0.4–0.9) | 117 (32.0) | 72 (25.4) | 0.6 (0.4–0.9) |
Duration of used | ||||||
≤ 4 yrs | 61 (13.4) | 47 (12.8) | 0.7 (0.4–1.1) | 46 (12.6) | 25 (8.8) | 0.6 (0.4–1.1) |
4–10 yrs | 58 (12.7) | 37 (10.1) | 0.5 (0.3–0.8) | 35 (9.6) | 23 (8.1) | 0.6 (0.3–1.1) |
>10 yrs | 59 (12.9) | 50 (13.7) | 0.7 (0.4–1.1) | 36 (9.8) | 24 (8.5) | 0.6 (0.4–1.1) |
P for linear trende | 0.020 | 0.029 | ||||
Aspirin | ||||||
Never | 333 (73.0) | 263 (71.9) | 1.0 (reference) | 249(78.3) | 211(84.4) | 1.0 (reference) |
Ever | 123 (27.0) | 103 (28.1) | 0.6 (0.4–0.9) | 69(21.7) | 39(15.6) | 0.5 (0.3–0.8) |
Duration of used | ||||||
≤ 4 yrs | 43 (9.4) | 32 (8.7) | 0.5 (0.3–0.9) | 27(8.5) | 10(4.0) | 0.4 (0.2–0.8) |
4–9 yrs | 41 (9.0) | 24 (6.6) | 0.3 (0.2–0.6) | 21(6.6) | 12(4.8) | 0.5 (0.2–1.0) |
>9 yrs | 39 (8.6) | 47 (12.8) | 0.9 (0.5–1.5) | 21(6.6) | 17(6.8) | 0.7 (0.4–1.4) |
P for linear trende | 0.114 | 0.038 | ||||
Ibuprofen | ||||||
Never | 399 (87.5) | 332 (90.7) | 1.0 (reference) | 257 (88.3) | 214 (89.5) | 1.0 (reference) |
Ever | 57 (12.5) | 34 (9.3) | 0.8 (0.5–1.2) | 34 (11.7) | 25 (10.5) | 0.9 (0.5–1.6) |
Duration of used | ||||||
≤ 3 yrs | 22 (4.8) | 15 (4.1) | 0.9 (0.5–1.9) | 11 (3.8) | 11 (4.6) | 1.5 (0.6–3.7) |
3–10 yrs | 16 (3.5) | 8 (2.2) | 0.5 (0.2–1.3) | 10 (3.4) | 7 (2.9) | 0.7 (0.3–2.0) |
>10 yrs | 19 (4.2) | 11 (3.0) | 0.8 (0.4–1.8) | 13 (4.5) | 7 (2.9) | 0.7 (0.3–1.8) |
P for linear trende | 0.244 | 0.484 |