Skip to main content
Figure 8 | BMC Urology

Figure 8

From: Bladder inflammatory transcriptome in response to tachykinins: Neurokinin 1 receptor-dependent genes and transcription regulatory elements

Figure 8

Direct comparison of TREs driving NK 1 R-dependent and-independent genes. The whole set of genes that were up-regulated at least 3-fold during bladder inflammation were analyzed in PAINT 3.3. These genes were divided into two groups: NK1R-dependent and NK1R-independent. A p-value threshold of 0.05 was used to derive statistically enriched regulatory elements in these two gene groups. Note that AP-1 is over represented in the set of NK1R-dependent genes, whereas it is not significantly correlated with NK1R-independent transcripts. Also note that Nkx-2.5 matrix _01 was found over represented in the set of NK1R-independent transcripts (colored in red) and under-represented or suppressed in the set of NK1R-dependent TRs (colored in cyan). In contrast, Nkx-2.5 matrix _02 had the completely opposite behavior.

Back to article page