Figure 1

Antihistamines specific for H1 receptor attenuate pelvic pain. A) Female mice treated by oral gavage with saline exhibited significantly increased pelvic sensitivity relative to baseline at PID 2, 3 and 4 for all filaments tested (n = 8, P < 0.05). B) Female mice treated by oral gavage with the H1R antagonist hydroxyzine showed a modest reduction in pelvic sensitivity that was significantly increased above baseline by PID 2, 3 and 4 (n = 9, P < 0.05). C) Female mice treated by oral gavage with the H1R antagonist diphenhydramine showed reduced pelvic sensitivity that was not significantly increased above baseline until PID 3 and 4 (n = 9, P < 0.05). D) Female mice treated by oral gavage with the H1R antagonist cetirizine showed reduced pelvic sensitivity that was not significantly increased above baseline until PID 3 and 4 (n = 9, P < 0.05). The symbol key shown in (A) applies to panels A-D. Error bars depict SEM, and significance was determined by ANOVA.