Skip to main content
Figure 3 | BMC Urology

Figure 3

From: Pharmacologic attenuation of pelvic pain in a murine model of interstitial cystitis

Figure 3

Substance P receptor antagonist and gabapentin attenuate pelvic pain. A) Female mice treated with saline (I.P.) exhibited significantly increased pelvic sensitivity relative to baseline at PID 2, 3 and 4 for all filaments tested (n = 5, P < 0.05). B) Female mice treated with gabapentin (I.P.) showed reduced pelvic sensitivity that was not significantly increased above baseline until PID 3 (n = 5, P < 0.05). C) Female mice treated with a substance P receptor antagonist L-703,606 did not develop significant pelvic sensitivity (n = 6). The symbol key shown in (A) applies to panels A-C. Error bars depict SEM, and significance was determined by ANOVA.

Back to article page