Treatment success for overactive bladder with urinary urge incontinence refractory to oral antimuscarinics: a review of published evidence

Campbell, Jonathan D; Gries, Katharine S; Watanabe, Jonathan H; Ravelo, Arliene; Dmochowski, Roger R; Sullivan, Sean D

doi:10.1186/1471-2490-9-18

Table 1 Complete Continence: Treatment Success Definition by Intervention

From: Treatment success for overactive bladder with urinary urge incontinence refractory to oral antimuscarinics: a review of published evidence

Study	Study Design	Sample Size	Study Population	Comparator	Success Evaluated (months)	Success %
Botulinum toxin type A
Kennelly, Top Spinal Cord Inj Rehabil, 2003 [26]	Open Label	10	NOAB	None	6	80
Reitz, Eur Urol, 2004 [27]	Open Label	200	NOAB	None	4	73
Giannantoni, J Urol, 2004 [28]	RCT	25	NOAB	Intravesically Resiniferation	18	73
Giannantoni, Minerva Urol Nephrol, 2004 [29]	RCT	12	NOAB	Intravesically Resiniferation	12	75.0
Klaphajone, Arch Phys Med Rehabil, 2005 [30]	Open Label	10	NOAB	None	1.5	70
Schurch, J Urol, 2005 [13]	RCT	38	NOAB	Placebo	6	63
Kessler, Neurourol Urodynam, 2005* [31]	Open Label	11, 11	NOAB, IOAB	None	3, 3	72, 91
Popat, J Urol, 2005* [32]	Open Label	31, 44	NOAB, IOAB	None	4, 4	55.2, 57
Werner, Am J Obstet Gynecol, 2005 [33]	Open Label	26	IOAB	None	9	65
Kuo, J Urol, 2006* [34]	Single Blind	35, 40	NOAB, IOAB	None	3, 3	94, 73
Giannantoni, J Urol, 2006 [35]	Open Label	23	NOAB	None	3	78
Karsenty, Urol, 2006 [36]	Open Label	17	NOAB	None	5	100
Sahai, J Urol, 2007 [37]	RCT	16	IOAB	Placebo	3	50
Mascarenhas, Neurourol. Urodynam, 2008 [38]	Open label	21	NOAB	None	2	42.8
Sacral neuromodulation
Bosch, J Urol, 2000 [39]	Open Label	6	NOAB	None	47	80
Chartier-Kastler, J Urol, 2000 [40]	Open Label	9	NOAB	None	43.6	67
Weil, Eur Urol, 2000 [41]	RCT	21	IOAB	Current Management	6	56
Spinelli, J Urol, 2001 [42]	Open Label	196	NOAB	None	18	71
Augmentation cystoplasty
Chartier-Kaslter, Spinal Cord, 2000 [43]	Open Label	17	NOAB	None	75.6	70.5
Ivil, Int Urol Nephrol, 2002 [44]	Open Label	17	IOAB	None	11	83
Khastgir, Eur Urol, 2003 [21]	Open Label	32	NOAB	None	72	100
Quek, J Urol, 2003 [45]	Open Label	26	NOAB	None	96	69
Stoffel, Neurourol Urodynam, 2006 [46]	Open Label	12	NOAB	None	20	88

* Denotes a study with both neurogenic OAB (NOAB) and idiopathic OAB (IOAB) populations.
Note: Studies may be listed in more than one category of treatment success if multiple definitions of treatment success were reported.

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ISSN: 1471-2490

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