Table 5 Table summarizes chemotherapeutic regimen used in the management of SCCB
From: Outcome of recurrent and metastatic small cell carcinoma of the bladder
Regimen | Schedule | Drugs and doses | Â | Â | Â | Â |
|---|---|---|---|---|---|---|
First line chemotherapy: Mixed and pure SCC | ||||||
On day 1 to 3, repeated after 21 days | Etoposide 120 mg/m2 on day 1 to 3 | Cisplatin 80–100 mg/m2, on day 1 |  |  |  | |
On day 1, 8, and 15, repeated every 28 days | Irinotecan 60 mg/m2 on days 1, 8 and 15 | Cisplatin 60 mg/m2 on day 1 | Â | Â | Â | |
VIP [21] | On day 1 to 4, repeated after 21 days | Ifosfamide 1.2 g/m2, on day 1 to 4 | Etoposide 75 mg/m2 on day 1 to 4 | Cisplatin 20 mg/m2 on day 1 to 4 | Â | Â |
EP/CAV [22] | Alternative regimen: PE on day 1 to 3 repeated after 42 days and CAV on day 1 repeated after 42 days | Etoposide 100 mg/m2 on day 1 to 3 | Cisplatin 80 mg/m2, on day 1 | Cyclophosphamide 800 mg/m2 | Doxorubicin 50 mg/m2 | Vincristine 1.4 mg/m2 |
First line: mixed SCC | ||||||
MVAC [18] | On day 1, 2, 15, and 22, repeated after 28 days | Methotrexate 30 mg/m2 on day 1, 15 and 22 | Vimblastine 3 mg/m2 on day 2, 15, and 22 | Doxorubicin 30 mg/m2 on day 2 | Cispatin 70 mg/m2 on day 2 | Â |
Second line chemotherapy in analogy to SCLC | ||||||
IV Topotecan [18] | On day 1 to 5, repeated every 21 days | Topotecan 1.5 mg/m2 on day 1 to 5 | Â | Â | Â | Â |
CAV | On day 1, repeated every 21 days | Cyclophosphamide 800 mg/m2 | Doxorubicin 50 mg/m2 | Vincristine 1.4 mg/m2 | Â | Â |
TP | On day 1 to 5, repeated every 21 days | Topotecan 0.75 mg/m2 on day 1 to 5 | Cisplatin 60 mg/m2 on day 1 | Â | Â | Â |