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Table 5 Table summarizes chemotherapeutic regimen used in the management of SCCB

From: Outcome of recurrent and metastatic small cell carcinoma of the bladder

Regimen Schedule Drugs and doses     
First line chemotherapy: Mixed and pure SCC
EP [18, 21, 22] On day 1 to 3, repeated after 21 days Etoposide 120 mg/m2 on day 1 to 3 Cisplatin 80–100 mg/m2, on day 1    
IP [28, 29] On day 1, 8, and 15, repeated every 28 days Irinotecan 60 mg/m2 on days 1, 8 and 15 Cisplatin 60 mg/m2 on day 1    
VIP [21] On day 1 to 4, repeated after 21 days Ifosfamide 1.2 g/m2, on day 1 to 4 Etoposide 75 mg/m2 on day 1 to 4 Cisplatin 20 mg/m2 on day 1 to 4   
EP/CAV [22] Alternative regimen: PE on day 1 to 3 repeated after 42 days and CAV on day 1 repeated after 42 days Etoposide 100 mg/m2 on day 1 to 3 Cisplatin 80 mg/m2, on day 1 Cyclophosphamide 800 mg/m2 Doxorubicin 50 mg/m2 Vincristine 1.4 mg/m2
First line: mixed SCC
MVAC [18] On day 1, 2, 15, and 22, repeated after 28 days Methotrexate 30 mg/m2 on day 1, 15 and 22 Vimblastine 3 mg/m2 on day 2, 15, and 22 Doxorubicin 30 mg/m2 on day 2 Cispatin 70 mg/m2 on day 2  
Second line chemotherapy in analogy to SCLC
IV Topotecan [18] On day 1 to 5, repeated every 21 days Topotecan 1.5 mg/m2 on day 1 to 5     
CAV On day 1, repeated every 21 days Cyclophosphamide 800 mg/m2 Doxorubicin 50 mg/m2 Vincristine 1.4 mg/m2   
TP On day 1 to 5, repeated every 21 days Topotecan 0.75 mg/m2 on day 1 to 5 Cisplatin 60 mg/m2 on day 1    
  1. EP = etoposide and cisplatin; VIP = etoposide, ifosfamide and cisplatin: PE/CAV = cisplatin and etoposide/cyclophosphamide, doxorubicin and vincristine; CEA = cyclophosphamide, etoposide and doxorubicin; CaE = carboplatin and etoposide; MVAC = methotrexate, vinmblastine, doxorubicin and cisplatin; IV = intravenous; SCC = small cell carcinoma; SCLC = small cell lung cancer