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Table 3 Unadjusted and adjusted ORs for UC by phenotypic and genotypic factors for patients with hematuria

From: A segregation index combining phenotypic (clinical characteristics) and genotypic (gene expression) biomarkers from a urine sample to triage out patients presenting with hematuria who have a low probability of urothelial carcinoma

   

Unadjusted OR (95% CI)

Adjusted P variable OR (95% CI)

Adjusted G + P variable OR (95% CI)

Phenotypic variables

Control (non-UC)

UC

   

Age, years

<60

151

11

2.30 (1.22–4.73)

2.24 (1.18–4.65)

1.89 (0.85–4.64)

≥60

364

61

Gender

Female

105

8

2.05 (1.01–4.75)

1.58 (0.76–3.72)

3.03 (1.12–9.36)

Male

410

64

Smoking history

Never smoked

227

19

2.20 (1.29–3.91)

2.19 (1.27–3.92)

2.67 (1.34–5.64)

Current or past smoker

288

53

Hfreq (average events/day)

≤1

300

32

1.74 (1.06–2.88)

1.80 (1.08–3.00)

1.76 (0.93–3.35)

>1

215

40

 

Unadjusted OR (95% CI)

Adjusted G variable OR (95% CI)

Adjusted G + P variable OR (95% CI)

Genotypic variables

   

IGFBP5

7.34 (4.59–12.33)

2.15 (1.03–4.58)

2.21 (1.03–4.83)

HOXA13

6.27 (3.92–10.34)

0.33 (0.13–0.83)

0.20 (0.07–0.56)

MDK

7.10 (4.73–11.10)

4.76 (1.74–13.62)

8.14 (2.64–26.60)

CDK1

7.80 (5.11–12.39)

3.47 (1.39–9.13)

2.59 (0.98–7.18)

CXCR2

1.69 (1.36–2.10)

0.65 (0.45–0.92)

0.69 (0.47–0.98)

  1. Adjusted P INDEX, G INDEX and G + P INDEX variable ORs are the exponentiated co-efficients in the P INDEX, G INDEX and G + P INDEX, respectively.