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Table 4 Performance characteristics of each model when thresholds are set for varying test negative rates as determined on the macroscopic hematuria population

From: A segregation index combining phenotypic (clinical characteristics) and genotypic (gene expression) biomarkers from a urine sample to triage out patients presenting with hematuria who have a low probability of urothelial carcinoma

Threshold (logOR)

Test-negative rate (95% CI)

NPV (95% CI)

Sensitivity (95% CI)

Specificity (95% CI)

P INDEX

-2.54

0.25 (0.21–0.28)

0.97 (0.92–0.99)

0.93 (0.85–0.98)

0.27 (0.23–0.31)

-2.52

0.38 (0.34–0.42)

0.95 (0.91–0.97)

0.83 (0.74–0.91)

0.41 (0.37–0.45)

-2.39

0.42 (0.37–0.45)

0.95 (0.91–0.97)

0.82 (0.72–0.90)

0.45 (0.40–0.49)

-1.95

0.51 (0.47–0.54)

0.92 (0.89–0.95)

0.68 (0.56–0.78)

0.53 (0.49–0.57)

-1.93

0.51 (0.46–0.55)

0.92 (0.89–0.95)

0.68 (0.56–0.78)

0.53 (0.49–0.58)

-1.73

0.82 (0.79–0.85)

0.90 (0.87–0.92)

0.32 (0.22–0.43)

0.84 (0.81–0.87)

G INDEX

-3.46

0.20 (0.17–0.23)

0.94 (0.88–0.97)

0.90 (0.80–0.95)

0.22 (0.18–0.25)

-3.23

0.30 (0.26–0.34)

0.95 (0.91–0.98)

0.89 (0.80–0.95)

0.33 (0.28–0.37)

-3.04

0.40 (0.36–0.44)

0.96 (0.92–0.98)

0.86 (0.77–0.93)

0.44 (0.40–0.48)

-2.86

0.50 (0.46–0.54)

0.97 (0.94–0.98)

0.86 (0.77–0.93)

0.55 (0.51–0.59)

-2.63

0.60 (0.56–0.63)

0.96 (0.94–0.98)

0.82 (0.71–0.90)

0.66 (0.62–0.69)

-2.41

0.70 (0.66–0.73)

0.96 (0.94–0.98)

0.78 (0.65–0.86)

0.77 (0.73–0.80)

G + P INDEX

-4.02

0.20 (0.17–0.23)

0.97 (0.93–0.99)

0.96 (0.88–0.99)

0.22 (0.19–0.26)

-3.67

0.30 (0.26–0.33)

0.98 (0.94–0.99)

0.94 (0.87–0.99)

0.33 (0.29–0.37)

-3.33

0.40 (0.36–0.44)

0.98 (0.95–1.00)

0.95 (0.86–0.98)

0.45 (0.40–0.49)

-2.99

0.50 (0.46–0.54)

0.98 (0.96–0.99)

0.92 (0.83–0.97)

0.56 (0.52–0.60)

-2.71

0.60 (0.56–0.64)

0.97 (0.95–0.99)

0.86 (0.76–0.93)

0.67 (0.63–0.71)

-2.37

0.70 (0.66–0.73)

0.97 (0.94–0.98)

0.80 (0.70–0.88)

0.77 (0.73–0.80)