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Figure 1 | BMC Urology

Figure 1

From: Protein kinase C modulates frequency of micturition and non-voiding contractions in the urinary bladder via neuronal and myogenic mechanisms

Figure 1

Concentration dependent effects of PKC stimulation by PDBu on spontaneous contractions of isolated detrusor strips. A, Spontaneous contractile activity of DSM strips upon increasing concentrations of PDBu (0–640 nM). At the initial concentration of 20 nM, PDBu inhibited spontaneous contractions, and caused a small but significant decrease in the baseline BSM tone. Continued application of PDBu reversed this decline and increased the muscle force above the initial basal levels. B, Summarized maximal amplitude of contractions indicates that PDBu significantly reduced PF generation (peak force, PF) at lower PDBu concentrations (20-40 nM; N = 5, n = 7 in each group, p < 0.05 to baseline).

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