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Figure 10 | BMC Urology

Figure 10

From: Protein kinase C modulates frequency of micturition and non-voiding contractions in the urinary bladder via neuronal and myogenic mechanisms

Figure 10

Cystometric evaluation of bladder function upon intravesical instillation of a PKC activator, PMA. A, Representative traces of intravesical pressure (top panel) and voided volume (lower panel) in rats instilled with normal saline. B, Representative traces of intravesical pressure (top panel) and voided volume (lower panel) in rats instilled with high concentration of PMA (50 μM). The rate of infusion was 80 μl/min. C, Perfusion of the urinary bladder in vivo with high PMA induced a significant increase in the frequency of micturition contractions, and a simultaneous decrease in the voided volume. D, Intravesical instillation of PMA also increased voiding frequency from 4 ± 0.5 to 8 ± 0.9 voids over the 2 h period (N = 4 in each group, p ≤ 0.05 to control).

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BMC Urology

ISSN: 1471-2490

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