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Figure 13 | BMC Urology

Figure 13

From: Protein kinase C modulates frequency of micturition and non-voiding contractions in the urinary bladder via neuronal and myogenic mechanisms

Figure 13

Inhibition of PKC activity by Bim-1 enhanced the number of non-voiding contractions recorded in vivo. A, Representative traces of intravesical pressure (top panel) and voided volume (lower panel) in a control rat instilled with saline. B, Representative traces of intravesical pressure (top panel) and voided volume (lower panel) in a rat instilled with intravesical Bim-1 (28 nM). Arrows point to non-voiding contractions. C, Changes in voided volume after pre-treatment with Bim-1. D, Number of non-voiding contractions after intravesical application of PKC inhibitor. Bim-1 decreased the voided volume by 56%, and increased the number of NVC 3.5-fold (p < 0.05, N = 4).

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BMC Urology

ISSN: 1471-2490

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