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Figure 14 | BMC Urology

Figure 14

From: Protein kinase C modulates frequency of micturition and non-voiding contractions in the urinary bladder via neuronal and myogenic mechanisms

Figure 14

Intravesical PKC activation restores urodynamic parameters when applied after treatment with PKC inhibitor, Bim-1. A, Changes in intravesical pressure (top panel) and volume of voided urine (bottom panel) during bladder perfusion with Bim-1 (28 nM) followed by instillation of 50 nM of PDBu. Low concentration of PDBu reversed the effects of Bim-1 by suppressing non-voiding contractions and increasing the voided volume to control levels. B, In order to determine whether or not the recovery to control levels was due to a washout effect of the Bim-1 during PDBu instillation, we repeated these experiments maintaining the concentration of Bim-1 but increasing the PDBu concentration to 100 nM. The results confirmed the previous findings demonstrating that application of PDBu after intravesical instillation of Bim-1 rescues bladder function. C, Comparison of the voided volume changes upon Bim-1 and PDBu applications, and upon PDBu application in the presence of Bim-1 (D).

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BMC Urology

ISSN: 1471-2490

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