Table 4 Utility weights per health state
Health state | Derivation | Utility weight |
|---|---|---|
Baseline | Based on average utilities of patients at baseline | 0.848 |
Response | Value at Week 12 | 0.887 |
No response | Value at Week 12 | 0.870 |
Second-line treatment | Average of response and no response health states | 0.879 |
Withdrawal | Assumed to be equal to the baseline utility | 0.848 |
Discontinuation | Assumed to be equal to the baseline utility | 0.848 |
Post-surgery | Derived by combining response utility value from NEPTUNE study with disutilities from [23], weighted by probability of improvement, no improvement and adverse events after surgery [23] | 0.839 |
Death | Lowest utility possible | 0.000 |