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Table 2 Differences in clinicopathologic results among the 3 groups stratified by the location of positive lymph nodes.

From: Oncologic outcomes in men with metastasis to the prostatic anterior fat pad lymph nodes: a multi-institution international study

 

Group 1, N = 206

Group 2, N = 63

Group 3, N = 25

P-value

Age, years: mean (SD)

63.3 (6.9)

63.3 (7.4)

64.4 (8.1)

0.744

PSA, ng/ml: mean (SD)

21.6 (36.0)

26.9 (85.5)

37.3 (66.5)

0.336

BCR-free survival, months: mean (range)

19.2 (0.7-77.7)

21.6 (1.0-76.3)

19.6 (2.6-60.0)

0.163

BCR: N (%)

   

0.073

 No

145 (70.4)

35 (55.6)

15 (60.0)

 

 Yes

61 (29.6)

28 (44.4)

10 (40.0)

 

D’Amico risk: N (%)

   

0.009

 Low risk

29 (14.1)

7 (11.1)

1 (4.0)

 

 Intermediate risk

65 (31.6)

17 (27.0)

1 (4.0)

 

 High risk

112 (54.4)

39 (61.9)

23 (92.0)

 

Biopsy GS: N (%)

   

<0.001

 6-7

116 (56.5)

25 (41.0)

5 (20.0)

 

 8-10

89 (43.4)

36 (59.0)

20 (80.0)

 

Pathologic GS: N (%)

   

0.021

 6-7

113 (54.9)

29 (46.0)

8 (32.0)

 

 8-10

93 (45.1)

34 (54.0)

17 (68.0)

 

Pathologic T stage: N (%)

   

0.005

 T2

81 (39.3)

18 (28.6)

3 (12.0)

 

 T3a

48 (23.3)

22 (34.9)

6 (24.0)

 

 T3b

59 (28.6)

19 (30.2)

10 (40.0)

 

 T4

18 (8.7)

4 (6.3)

6 (24.0)

 

Margin status: N (%)

   

0.043

 Negative

69 (33.5)

37 (58.7)

9 (36.0)

 

 Positive

137 (66.5)

26 (41.3)

16 (64.0)

 

Adjuvant therapy: N (%)

   

0.012

 No

165 (80.1)

42 (66.7)

16 (64.0)

 

 Yes

41 (19.9)

21 (33.3)

9 (36.0)

 
  1. Group 1, Pelvic LN metastasis only; Group 2, PAFP LN metastasis only; Group 3, Both pelvic LN & PAFP LN metastasis; PSA, Prostate-specific antigen; BCR, Biochemical recurrence; GS, Gleason score