Fig. 2

IL-2C treatment induces the expansion of immune cells in the spleen of mice with RCC. Syngeneic RENCA cells were implanted subcutaneously in mice, and IL-2C or PBS was administered every other day for 4 weeks. (a) The number of CD4⁺ T cells was similar between the two groups (P = 0.498), while the numbers of (b) CD8⁺ T cells, (c) CD8⁺ memory T cells, (d) NK cells, (e) macrophages, and (f) Tregs were higher in the IL-2C group than in the PBS group (P < 0.010). (g, h) CD8⁺ memory T cell/Treg and NK cell/Treg ratios were higher in the IL-2C group than the PBS group (P < 0.010 in both cases). Treg, regulatory T cell