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Fig. 4 | BMC Urology

Fig. 4

From: Global expression of AMACR transcripts predicts risk for prostate cancer – a systematic comparison of AMACR protein and mRNA expression in cancerous and noncancerous prostate

Fig. 4

Immunohistochemical analysis of AMACR protein expression in different prostatic lesions. Hematoxylin-eosin (HE) and AMACR staining from the same region of interest are shown. a, b Typical acinar Gleason 3 + 4 adenocarcinoma stains strongly for AMACR (open arrow) while the normal glands are AMACR negative (filled arrow). c, d Gleason 4 + 5 adenocarcinoma shows focal positive staining for AMACR (open arrow) while some of the poorly differentiated carcinoma glands (open arrowhead) and normal glands (filled arrow) are AMACR negative. e, f: High grade PIN lesion shows positive AMACR staining (filled arrowhead) while morphologically normal glands show weak or no AMACR staining (filled arrow). Scale bar 200 μm (a-b), 100 μm (c-f)

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BMC Urology

ISSN: 1471-2490

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