[−2]proPSA versus ultrasensitive PSA fluctuations over time in the first year from radical prostatectomy, in an high-risk prostate cancer population: A first report

Table 2 Mixed linear models for uPSA and [−2]proPSA repeated measures

uPSA	Univariate model	Multivariate model	[−2]proPSA	Univariate model	Multivariate model
Covariate	p	p	Covariate	p	p
Time trend	<0.001	<0.001	Time trend	<0.001	<0.001
Age >65 years	0.095	0.455	Age >65 years	0.472
BMI >26	0.059	0.507	BMI >26	0.315
PSA at diagnosis >8 ng/ml	0.015	0.014	PSA at diagnosis >8 ng/ml	0.032	0.012
Positive DRE	0.168		Positive DRE	0.241
Biopsy samples >5	0.365		Biopsy samples >5	0.483
GS at biopsy >7	0.419		GS at biopsy >7	0.349
MRI lesions >1	0.178		MRI lesions >1	0.607
Prostate volume >40 ml	0.214		Prostate volume >40 ml	0.472
Tumor percentage >10 %	0.522		Tumor percentage >10 %	0.658
Positive margins	0.018	0.214	Positive margins	0.822
GS at surgery >7	0.209		GS at surgery >7	0.102
Capsule involvement	0.039		Capsule involvement	0.077
Neural involvement	0.216		Neural involvement	0.603
Vascular involvement	0.110		Vascular involvement	0.083	0.952
pT	<0.001	0.038	pT	0.008	0.879
pN	<0.001	0.001	pN	0.008	<0.001
			BCR (uPSA +0,2 ng/ml)	0.096
			BCR (3 rising uPSA values)	0.194
pT*pN (interaction)	-	0.639	PSA at diagnosis*pN (interaction)	-	0.099

ISSN: 1471-2490