Table 3 Univariate and Multivariate analysis results for PFS and OS
Variable | Univariate | Multivariate Model 1 | Multivariate Model 2 | |||
|---|---|---|---|---|---|---|
PFS HR (95% CI), P-value | OS HR (95% CI), P-value | PFS HR (95% CI), P-value | OS HR (95% CI), P-value | PFS HR (95% CI), P-value | OS HR (95% CI), P-value | |
Sex | ||||||
Male vs Female | 0.49 (0.27-0.93), p = .031 | 0.35 (0.17-0.71), p = .005 | 0.64 (0.33-1.28), p = .20 | 0.67 (1.09-5.46), p = .33 | 0.56 (0.30-1.08), p = .08 | 0.45 (0.22-0.93), p = .03 |
IMDC Criteria | ||||||
Favorable | ref | ref | ref | ref | ref | ref |
Intermediate | 2.20 (0.93-6.50), p = .08 | 4.13 (1.23-25.62), p = .02 | 2.02 (0.83-6.06), p = .13 | 4.02 (1.16-25.33), p = .03 | 1.91 (0.78-5.73), p = .17 | 3.42 (1.00-21.48), p = 0.05 |
Poor | 4.46 (1.56-14.65), p = .005 | 10.43 (2.65-69.34), p = .0004 | 3.38 (1.12-11.55), p = .03 | 7.00 (1.68-47.83), p = .006 | 3.23 (1.03-11.30), p = .04 | 5.41 (1.20-38.24), p = .03 |
NLR | ||||||
≤ 4 vs >4 | 0.51 (0.28-0.95), p = .034 | 0.31 (0.16-0.61), p = .001 | 0.68 (0.35-1.39), p = .28 | 0.41 (1.09-5.46), p = .03 | NA | NA |
Continuous (per unit change in NLR | 1.05 (0.99-1.10), p = .08 | 1.10 (1.04-1.15), p = .002 | NA | NA | 1.03 (0.97-1.09), p = .30 | 1.08 (1.01-1.14), p = .03 |