Fig. 1

PD-L1/2 expression in pRCC a Pictures of immunostaining of PD-L1/2 in two cell lines (PD-L1/2-positive cell line; ATL-T, PD-L1/2-negative cell line; DAUDI) b Pictures of H.E. staining and immunostaining of PD-L1 in 2 cases of pRCC. Positive signals are detected most strongly in cancer cells c Positive signals for PD-L1 are also detected in macrophages d Positive signals for PD-L1 are also detected in neuronal fibers e PD-L2 is detected in dendritic cells in the lymph node, whereas no PD-L2 is observed in the cancer cells of any of the pRCC cases