Table 2 Summary of all clinical studies
Author, year [reference] | Study design | Patients number (response rate) | Controls Number (response rate) | Comparator | Outcomes measured |
|---|---|---|---|---|---|
Buck AC. 1989 [23] | Prospective trial (phase II) | 15 (86.6) | - | - | - pollen extract effective in the treatment of chronic prostatitis and prostatodynia. |
Cai T. 2013 [11] | Prospective trial (phase II) | 20 (90.0) | - | - | - pollen extract significantly improved total symptoms, pain, and QoL in patients with non-inflammatory CP/CPPS without severe side effects. |
Cai T, 2014 [27] | Randomized controlled trial | 41 (75.6) | 46 (41.3) | ibuprofen | - pollen extract significantly improved quality of life of patients when compared with those treated with ibuprofen (treatment difference in the NIH-CPSI pain domain, -2.14 ± 0.51, P < 0.001; QoL scores, P = 0.002). |
Elist J. 2006 [28] | Randomized controlled trial | 30 (73.3) | 28 (64.2) | Placebo | - pollen extract is superior to placebo in providing symptomatic relief in men with chronic nonbacterial prostatitis/chronic pelvic pain syndrome. |
Iwamura H, 2015 [29] | Randomized placebo-controlled trial | 50 (78.1) | 50 (88.2) | Eviprostat (phytotherapeutic agent) | - pollen extract significantly reduced the symptoms of category III CP/CPPS without any adverse events, in terms of NIH-CPSI, IPSS, and QoL. |
Jodai A, 1988 [24] | Prospective trial (phase II) | 32 (75.0) | - | - | - pollen extract significantly reduced the symptoms in 75.0% of all treated patients. |
Monden K. 2002 [25] | Prospective trial (phase II) | 24 (91.6) | - | - | - pollen extract significantly reduced the symptoms of chronic prostatitis group |
Rugendorff EW. 1993 [10] | Prospective trial (phase II) | 90 (62.2) | - | - | - pollen extract significantly reduced the symptoms of category III CP/CPPS without any adverse events, in terms of urinary symptoms and QoL. |
Suzuki T. 1992 [26] | Prospective trial (phase II) | 25 (96.0) | - | - | - pollen extract significantly reduced the symptoms of prostatitis patients without any adverse events. |
Wagenlehner FM. 2009 [13] | Randomized controlled trial | 70 (70.6) | 69 (49.3) | Placebo | - pollen extract significantly improved total symptoms, pain, and QoL in patients with inflammatory CP/CPPS without severe side-effects. |