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Table 4 Comparison of PSM & BCR with previously published data

From: Positive surgical margins and biochemical recurrence following minimally-invasive radical prostatectomy – An analysis of outcomes from a UK tertiary referral centre

  

Ref

Study period

Total number of patients

Pre-operative PSA mean (median) in ng/mL

Median tumour vol. (cc)

Surgical approach

PSM rate (%)

Stratified by pathological stage

% BCR

Stratified by

margin status

Median follow-up

% LRP

% Open

% RARP

pT2

pT3a

pT3b

PSM

NSM

This study

Freeman Hospital, UK

-

2002-2014

592

3.65 (2.4)

PSM 3.9 NSM 2.0

66.4%

-

33.6%

30.6%

21.9%

45.6%

66.7%

6.7%

10.7%

5.1%

4.4 years

Wright et al.

SEER, USA

[13]

1998-2006

65,633

-

-

-

-

-

21.2%

17.7%

43.8%

-

-

-

-

N/A

Mauermann et al.

Quebec, Canada

[22]

1987-2010

1,712

8.5 (6.8)

-

10.6%

89.4%

-

34.5%

27.6%

54.1%

49.5%*

16.4%

26.7%

10.9%

6 years

Ficarra et al.

Padua, Italy

[14]

2005-2008

322

-

-

-

-

100.0%

29.5%

10.6%

57.5%

72.2%

3.2%

6.2%

1.8%

1 year

Patel et al.

Multi-institution

[15]

2002-2009

8,418

-

-

-

-

100.0%

15.7%

9.5%

33.2%

48.2%

-

-

-

N/A

Boorjian et al.

Mayo Clinic, USA

[32]

1990-2006

11,729**

PSM (5.9) NSM (8.1)

PSM 3.3 NSM 1.1

-

100.0%

-

31.1%

23.4%

52.9%

55.4%

25.6%

44.0%

23.0%

8.2 years

Chalfin et al.

John Hopkins, USA

[21]

1982-2011

4,461

6.8 (5.4)

-

-

100.0%

-

10.4%

14.6%

22.2%

31.5%

16.7%

54.5%

12.3%

10 years

Sooriakumaran et al.

Stockholm

[16]

2002-2006

944

6.4

-

-

-

100.0%

21.6%

16.0%

33.3%

57.9%

15.2%

29.0%

12.0%

6.3 years

Evans et al.

Victoria, Australia

[33]

2008-2012

2219

-

-

8.1%

53.0%

38.8%

27.2%

16.1%

50.7%

 

-

-

-

N/A

Sukumar et al.

Detroit, USA

[17]

2001-2010

4803

6.1

Mean 7.5

-

-

100.0%

24.7%

11.2%

50.5%

 

9.8%

-

-

2.2 years

Abdollah et al.

Multi-institution

[18]

2001-2010

5670

6.4 (5.2)

-

  

100.0%

24.0%

 

34.3%***

14.1%

-

-

4.2 years

Gnanapragasam et al.

Cambridge, UK

[9]

2005-2015

1500

8.5 (7.3)

-

  

100.0%

21.5%

9.1%

29.6%

53.6%

-

-

-

N/A

Range

        

10.4-34.5%

9.1-27.6%

22.2-57.4%

31.5-72.2%

3.2-25.6%

6.2-54.5%

1.8-23.0%

1-10 years

  1. *Includes pT4 (2002 TNM staging, changed to pT3b in 2010); **Patients with N1 disease excluded (PSM rate 295/484 = 61%); ***High-risk D'Amico group
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BMC Urology

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